Effects of Fragrance-Loaded Mesoporous Silica Nanocolumns on Central Nervous System

doi:10.1166/jbn.2018.2607

	Effects of Fragrance-Loaded Mesoporous Silica Nanocolumns on Central Nervous System
	Lu, ZG; Zhang, TL; Shen, J; Xiao, ZB; Hu, J; Niu, YW; Yu, D; Chen, L; Zhang, X; Lu, Zhiguo
刊名	JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
	2018
卷号	14 期号:9 页码:1578
关键词	Sandela 803 ELEVATED PLUS-MAZE Light-Activated Release POLY(ETHYLENE GLYCOL) Central Nervous System SUBSTANTIA-NIGRA Neural Activity SIRNA DELIVERY Nerve Regeneration SANTALUM-ALBUM OPEN-FIELD RELEASE MEMORY NANOPARTICLES RATS
ISSN号	1550-7033
DOI	10.1166/jbn.2018.2607
文献子类	Article
英文摘要	Fragrances have rapid effect on our central nervous system, such as making the spirit of relaxation, relieving tensions and refreshing ourselves. However, the release of fragrances is not stable. Here, we added photo-driven mesoporous silica nanocolumns loaded with sandela 803 (MS-C@S803) into wallpaper to obtain fragrant wallpaper (MS-C-W@S803). We then analysed the effects of MS-C-W@S803 and pure sandela 803 treated wallpaper (W@S803) on the CNS of mice and explored the internal mechanism of these effects. Besides, we evaluated the short-term (7 days) and long-term (30 days) effects of the fragrance treated wallpaper. In behaviouristics level, we detected the anxiolytic effects via elevated plus maze and open field test. In tissue level, we analysed the neural activity in hippocampus, hypothalamus and olfactory bulb regions via measuring the electrophysiological signal. In cell level, we tested the nerve regeneration in hippocampus, substantia nigra and corpus striatum via immunofluorescence staining with the anti-BrdU antibody. In molecule level, we measured the expression of dopamine, acetylcholine, gamma-aminobutyric acid (GABA) and N-methyl-D-aspartic acid (NMDA) via liquid chromatography-mass spectrometry. Finally, we find that MS-C-W@S803 had anxiolytic effects on the CNS of mice, and the effects were more significant as time progresses.
WOS记录号	WOS:000437426600005
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/26755]
专题	中国科学院过程工程研究所
推荐引用方式 GB/T 7714	Lu, ZG,Zhang, TL,Shen, J,et al. Effects of Fragrance-Loaded Mesoporous Silica Nanocolumns on Central Nervous System[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2018,14(9):1578, 1589.
APA	Lu, ZG.,Zhang, TL.,Shen, J.,Xiao, ZB.,Hu, J.,...&Zhang, Xin.(2018).Effects of Fragrance-Loaded Mesoporous Silica Nanocolumns on Central Nervous System.JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,14(9),1578.
MLA	Lu, ZG,et al."Effects of Fragrance-Loaded Mesoporous Silica Nanocolumns on Central Nervous System".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 14.9(2018):1578.