Antiferromagnetic Pyrite as the Tumor Microenvironment-Mediated Nanoplatform for Self-Enhanced Tumor Imaging and Therapy

doi:10.1002/adma.201701683

	Antiferromagnetic Pyrite as the Tumor Microenvironment-Mediated Nanoplatform for Self-Enhanced Tumor Imaging and Therapy
	Tang, Zhongmin 1,2; Zhang, Huilin 3; Liu, Yanyan 3; Ni, Dalong 1; Zhang, Hua 4; Zhang, Jiawen 4; Yao, Zhenwei 4; He, Mingyuan 3; Shi, Jianlin 1,2,3; Bu, Wenbo 1,2,3
刊名	Advanced Materials
	2017
卷号	29 期号:47
ISSN号	09359648
DOI	10.1002/adma.201701683
英文摘要	Several decades of research have identified the specific tumor microenvironment (TME) to develop promising nanotheranostics, such as pH-sensitive imaging, acidity-sensitive starving therapy, and hydrogen peroxide-activated chemotherapy, etc. Herein, a novel TME-mediated nanoplatform employing antiferromagnetic pyrite nanocubes is presented, exploiting the intratumoral, overproduced peroxide for self-enhanced magnetic resonance imaging (MRI) and photothermal therapy (PTT)/chemodynamic therapy (CDT). Through the activation of excessive peroxide in the tumor microenvironment, pyrite can lead to in situ surface oxidation and generate hydroxyl radicals to kill tumor cells (i.e., CDT). The increase of the valence state of surface Fe significantly promotes the performance of MRI accompanied by CDT. Furthermore, the localized heat by photothermal treatment can accelerate the intratumoral Fenton process, enabling a synergetic PTT/CDT. To our best knowledge, this is the first study to use the TME-response valence-variable strategy based on pyrite for developing a synergetic nanotheranostic, which will open up a new dimension for the design of other TME-based anticancer strategies. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/25534]
专题	中国科学院上海硅酸盐研究所
作者单位	1.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China; 2.Shanghai Institute of Ceramics, University of Chinese Academy of Sciences, Beijing; 100049, China; 3.Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai; 200062, China; 4.Department of Radiology, Huashan Hospital, Fudan University, Shanghai; 200040, China
推荐引用方式 GB/T 7714	Tang, Zhongmin,Zhang, Huilin,Liu, Yanyan,et al. Antiferromagnetic Pyrite as the Tumor Microenvironment-Mediated Nanoplatform for Self-Enhanced Tumor Imaging and Therapy[J]. Advanced Materials,2017,29(47).
APA	Tang, Zhongmin.,Zhang, Huilin.,Liu, Yanyan.,Ni, Dalong.,Zhang, Hua.,...&Bu, Wenbo.(2017).Antiferromagnetic Pyrite as the Tumor Microenvironment-Mediated Nanoplatform for Self-Enhanced Tumor Imaging and Therapy.Advanced Materials,29(47).
MLA	Tang, Zhongmin,et al."Antiferromagnetic Pyrite as the Tumor Microenvironment-Mediated Nanoplatform for Self-Enhanced Tumor Imaging and Therapy".Advanced Materials 29.47(2017).