Silicon-Enhanced Adipogenesis and Angiogenesis for Vascularized Adipose Tissue Engineering

doi:10.1002/advs.201800776

	Silicon-Enhanced Adipogenesis and Angiogenesis for Vascularized Adipose Tissue Engineering
	Wang, Xiaoya 1; Gao, Long 1,2; Han, Yan 1; Xing, Min 1,2; Zhao, Cancan 1,2; Peng, Jinliang 3; Chang, Jiang 1
刊名	Advanced Science
	2018
DOI	10.1002/advs.201800776
英文摘要	The enhancement of adipogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and sufficient vascularization remain great challenges for the successful reconstruction of engineered adipose tissue. Here, the bioactive effects of silicon (Si) ions on adipogenic differentiation of human BMSCs (HBMSCs) and the stimulation of vascularization during adipose tissue regeneration are reported. The results show that Si ions can enhance adipogenic differentiation of HBMSCs through the stimulation of the expression of adipogenic differentiation switches such as peroxisome proliferator-activated receptor γ and CCAAT/enhancer-binding protein α. Furthermore, Si ions can enhance both angiogenesis and adipogenesis, and inhibit dedifferentiation of cocultured adipocytes by regulating the interactions between HBMSC-derived adipocytes and human umbilical vein endothelial cells, in which the promotion of the expression of insulin-like growth factor 1 and vascular endothelial growth factor plays vital roles. The in vivo studies further demonstrate that the designed composite hydrogel with the ability to release bioactive Si ions clearly stimulates neovascularization and adipose tissue regeneration. The study suggests that Si ions released from biomaterials are important chemical cues for adipogenic differentiation and biomaterials with the ability to release Si ions can be designed for adipose tissue engineering. © 2018 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
出版者	John Wiley and Sons Inc.
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/25150]
专题	中国科学院上海硅酸盐研究所
作者单位	1.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai; 200050, China; 2.University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing; 100049, China; 3.School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai; 200240, China
推荐引用方式 GB/T 7714	Wang, Xiaoya,Gao, Long,Han, Yan,et al. Silicon-Enhanced Adipogenesis and Angiogenesis for Vascularized Adipose Tissue Engineering[J]. Advanced Science,2018.
APA	Wang, Xiaoya.,Gao, Long.,Han, Yan.,Xing, Min.,Zhao, Cancan.,...&Chang, Jiang.(2018).Silicon-Enhanced Adipogenesis and Angiogenesis for Vascularized Adipose Tissue Engineering.Advanced Science.
MLA	Wang, Xiaoya,et al."Silicon-Enhanced Adipogenesis and Angiogenesis for Vascularized Adipose Tissue Engineering".Advanced Science (2018).