Injectable nano-structured silicon-containing hydroxyapatite microspheres with enhanced osteogenic differentiation and angiogenic factor expression

doi:10.1016/j.ceramint.2018.08.040

	Injectable nano-structured silicon-containing hydroxyapatite microspheres with enhanced osteogenic differentiation and angiogenic factor expression
	Sun, Wenjun 1; Zhou, Yuning 2; Zhang, Xinran 1; Xia, Wei 3; Xu, Yuanjin 2; Lin, Kaili 1,4
刊名	Ceramics International
	2018
卷号	44 期号:16 页码:20457-20464
ISSN号	02728842
DOI	10.1016/j.ceramint.2018.08.040
英文摘要	Injectable bioactive ceramics with excellent osteogenesis play important roles in bone regeneration field. In this study, we creatively fabricated the injectable nano-structured silicon-containing hydroxyapatite (Si-HAp) microspheres in diameter of 70–100 µm via hydrothermal treatment of calcium silicate (CaSiO3) microspheres in Na3PO4 aqueous solution. The fabricated Si-HAp microspheres were constructed by nano-rods with a diameter of 100 nm and length up to 1.5 µm. Comparing with the pure HAp microspheres, the obtained nano-structured Si-HAp microspheres exhibited excellent protein loading properties and sustained protein release capacities. Most importantly, the Si-substitution could apparently enhance the proliferation, osteogenic differentiation and the genes expression of angiogenic factors of rat bone marrow mesenchymal stem cells (rBMSCs). These all indicated that the nano-structured Si-HAp microspheres fabricated via hydrothermal transformation method might be used as promising injectable bioactive biomaterials and drug deliveries for bone regeneration. © 2018 Elsevier Ltd and Techna Group S.r.l.
出版者	Elsevier Ltd
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/25131]
专题	中国科学院上海硅酸盐研究所
作者单位	1.School & Hospital of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai; 200072, China; 2.Department of Oral Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai; 200011, China; 3.Applied Materials Science, Department of Engineering Science, Uppsala University, Ångströmlaboratoriet, Lägerhyddsv 1, Box 534, Uppsala; 75121, Sweden; 4.Department of Oral & Cranio-Maxillofacial Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai; 200011, China
推荐引用方式 GB/T 7714	Sun, Wenjun,Zhou, Yuning,Zhang, Xinran,et al. Injectable nano-structured silicon-containing hydroxyapatite microspheres with enhanced osteogenic differentiation and angiogenic factor expression[J]. Ceramics International,2018,44(16):20457-20464.
APA	Sun, Wenjun,Zhou, Yuning,Zhang, Xinran,Xia, Wei,Xu, Yuanjin,&Lin, Kaili.(2018).Injectable nano-structured silicon-containing hydroxyapatite microspheres with enhanced osteogenic differentiation and angiogenic factor expression.Ceramics International,44(16),20457-20464.
MLA	Sun, Wenjun,et al."Injectable nano-structured silicon-containing hydroxyapatite microspheres with enhanced osteogenic differentiation and angiogenic factor expression".Ceramics International 44.16(2018):20457-20464.