Copper Silicate Hollow Microspheres-Incorporated Scaffolds for Chemo-Photothermal Therapy of Melanoma and Tissue Healing

doi:10.1021/acsnano.7b08928

	Copper Silicate Hollow Microspheres-Incorporated Scaffolds for Chemo-Photothermal Therapy of Melanoma and Tissue Healing
	Yu, Qingqing 1; Han, Yiming 2,3; Wang, Xiaocheng 1; Qin, Chen 1; Zhai, Dong ; Yi, Zhengfang 2,3; Chang, Jiang ; Xiao, Yin 4; Wu, Chengtie
刊名	ACS NANO
	2018
卷号	12 期号:3 页码:2695
关键词	copper silicate photothermal therapy chemotherapy melanoma tissue healing
ISSN号	1936-0851
DOI	10.1021/acsnano.7b08928
英文摘要	The treatment of melanoma requires complete removal of tumor cells and simultaneous tissue regeneration of tumor-initiated cutaneous defects. Herein, copper silicate hollow microspheres (CSO HMSs)-incorporated bioactive scaffolds were designed for chemo-photothermal therapy of skin cancers and regeneration of skin tissue. CSO HMSs were synthesized with interior hollow and external nanoneedle microstructure, showing excellent drug-loading capacity and photothermal effects. With incorporation of drug-loaded CSO HMSs into the electrospun scaffolds, the composite scaffolds exhibited excellent photothermal effects and controlled NIR-triggered drug release, leading to distinctly synergistic chemo-photothermal therapy of skin cancer both in vitro and in vivo. Furthermore, such CSO HMSs-incorporated scaffolds could promote proliferation and attachment of normal skin cells and accelerate skin tissue healing in tumor-bearing and diabetic mice. Taken together, CSO HMSs-incorporated scaffolds may be used for complete eradication of the remaining tumor cells after surgery and simultaneous tissue healing, which offers an effective strategy for therapy and regeneration of tumor initiated tissue defects.
学科主题	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000428972600064
资助机构	This work was partially supported by National Key Research and Development Program of China (2016YFC1100200), Key Research Program of Frontier Sciences, CAS (QYZDB-SSW-SYS027), and Science and Technology Commission of Shanghai Municipality (17441903700, 17540712300). ; This work was partially supported by National Key Research and Development Program of China (2016YFC1100200), Key Research Program of Frontier Sciences, CAS (QYZDB-SSW-SYS027), and Science and Technology Commission of Shanghai Municipality (17441903700, 17540712300).
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/25116]
专题	中国科学院上海硅酸盐研究所
作者单位	1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, 1295 Dingxi Rd, Shanghai 200050, Peoples R China 2.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China 3.East China Normal Univ, Inst Biomed Sci, Shanghai Key Lab Regulatory Biol, 500 Dongchuan Rd, Shanghai 200241, Peoples R China 4.East China Normal Univ, Sch Life Sci, 500 Dongchuan Rd, Shanghai 200241, Peoples R China 5.Queensland Univ Technol, Inst Hlth & Biomed Innovat, 80 Musk Ave, Brisbane, Qld 4059, Australia
推荐引用方式 GB/T 7714	Yu, Qingqing,Han, Yiming,Wang, Xiaocheng,et al. Copper Silicate Hollow Microspheres-Incorporated Scaffolds for Chemo-Photothermal Therapy of Melanoma and Tissue Healing[J]. ACS NANO,2018,12(3):2695, 2707.
APA	Yu, Qingqing.,Han, Yiming.,Wang, Xiaocheng.,Qin, Chen.,Zhai, Dong.,...&Wu, Chengtie.(2018).Copper Silicate Hollow Microspheres-Incorporated Scaffolds for Chemo-Photothermal Therapy of Melanoma and Tissue Healing.ACS NANO,12(3),2695.
MLA	Yu, Qingqing,et al."Copper Silicate Hollow Microspheres-Incorporated Scaffolds for Chemo-Photothermal Therapy of Melanoma and Tissue Healing".ACS NANO 12.3(2018):2695.