Enhancement of tendon-bone healing following rotator cuff repair using hydroxyapatite with TGF1

doi:10.3892/mmr.2018.8499

	Enhancement of tendon-bone healing following rotator cuff repair using hydroxyapatite with TGF1
	You, Xiebo ; Shen, Yueqin 1; Yu, Weihan ; He, Yaohua
刊名	MOLECULAR MEDICINE REPORTS
	2018
卷号	17 期号:4 页码:4981
关键词	hydroxyapatite transforming growth factor 1 rotator cuff tear tendon-bone healing
ISSN号	1791-2997
DOI	10.3892/mmr.2018.8499
英文摘要	The formation of fibrocartilage at the healing site following a rotator cuff tear repair is a major problem in the field of tendon-bone healing. The present study aimed to enhance the healing of the tendon-bone interface following rotator-cuff tear repair by the interposition of hydroxyapatite (HA) encapsulated with transforming growth factor 1 (TGF1). Using an acute rotator cuff repair model, rats were divided into three groups: i) Repair only (control); ii) HA group; and iii) HA-TGF1 group. Animals were sacrificed at 2, 4 and 8 weeks following surgery. Micro-computed tomography (CT), histomorphometric analyses and biomechanical tests were used to evaluate the supraspinatus tendon-bone complex. The micro-CT images revealed notable novel bone formation in the groups treated with HA-TGF1. The histomorphometric analyses demonstrated improved fibrocartilage formation and collagen organization at the tendon-bone interface. The HA-TGF1 combination significantly improved the area of fibrocartilage, particularly at early time points (2 and 4 weeks). There was a significantly greater load-to-failure force achieved in the HA and HA-TGF1 groups compared with the control group at 4 and 8 weeks. Augmentation of the ceramic powder with HA-TGF1 at the tendon-bone interface was demonstrated to strengthen the healing entheses, increase bone and fibrocartilage formation and improve collagen organization compared with surgical repair alone. Local application of HA-TGF1 demonstrates potential in improving tendon-bone healing following rotator cuff repair.
学科主题	Oncology ; Medicine, Research & Experimental
出版者	SPANDIDOS PUBL LTD
WOS记录号	WOS:000428672100015
资助机构	Financial support from the National Natural Science Foundation of China (grant nos. 81271961 and 81572106) is gratefully acknowledged. ; Financial support from the National Natural Science Foundation of China (grant nos. 81271961 and 81572106) is gratefully acknowledged.
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/25042]
专题	中国科学院上海硅酸盐研究所
作者单位	1.Shanghai Jiao Tong Univ, Dept Orthoped, Affiliated Peoples Hosp 6, 600 Yishan Rd, Shanghai 200233, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China
推荐引用方式 GB/T 7714	You, Xiebo,Shen, Yueqin,Yu, Weihan,et al. Enhancement of tendon-bone healing following rotator cuff repair using hydroxyapatite with TGF1[J]. MOLECULAR MEDICINE REPORTS,2018,17(4):4981, 4988.
APA	You, Xiebo,Shen, Yueqin,Yu, Weihan,&He, Yaohua.(2018).Enhancement of tendon-bone healing following rotator cuff repair using hydroxyapatite with TGF1.MOLECULAR MEDICINE REPORTS,17(4),4981.
MLA	You, Xiebo,et al."Enhancement of tendon-bone healing following rotator cuff repair using hydroxyapatite with TGF1".MOLECULAR MEDICINE REPORTS 17.4(2018):4981.