NIR-Triggered Crystal Phase Transformation of NiTi-Layered Double Hydroxides Films for Localized Chemothermal Tumor Therapy

doi:10.1002/advs.201700782

	NIR-Triggered Crystal Phase Transformation of NiTi-Layered Double Hydroxides Films for Localized Chemothermal Tumor Therapy
	Wang, Donghui 1; Ge, Naijian 2; Yang, Tingting 1; Peng, Feng 1; Qiao, Yuqin ; Li, Qianwen 1; Liu, Xuanyong
刊名	ADVANCED SCIENCE
	2018
卷号	5 期号:4
关键词	chemothermal therapy crystal phase change layered double hydroxides near infrared
ISSN号	2198-3844
DOI	10.1002/advs.201700782
英文摘要	Construction of localized drug-eluting systems with synergistic chemothermal tumor-killing abilities is promising for biomedical implants directly contacting with tumor tissues. In this study, an intelligent and biocompatible drug-loading platform, based on a gold nanorods-modified butyrate-inserted NiTi-layered double hydroxides film (Au@LDH/B), is prepared on the surface of nitinol alloy. The prepared films function as drug-loading "sponges," which pump butyrate out under near-infrared (NIR) irradiation and resorb drugs in water when the NIR laser is shut off. The stimuli-responsive release of butyrate is verified to be related with the NIR-triggered crystal phase transformation of Au@LDH/B. In vitro and in vivo studies reveal that the prepared films possess excellent biosafety and high efficiency in synergistic thermochemo tumor therapy, showing a promising application in the construction of localized stimuli-responsive drug-delivery systems.
学科主题	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
出版者	WILEY
WOS记录号	WOS:000430460200020
资助机构	D.H.W, N.J.G., and T.T.Y. contributed equally to this work. Financial support from the National Key Research and Development Program of China (2017YFB0702600, 2017YFB0702602), National Science Foundation for Distinguished Young Scholars of China (51525207), National Natural Science Foundation of China (31570973), and Shanghai Committee of Science and Technology, China (15441904900, 14XD1403900) are acknowledged. ; D.H.W, N.J.G., and T.T.Y. contributed equally to this work. Financial support from the National Key Research and Development Program of China (2017YFB0702600, 2017YFB0702602), National Science Foundation for Distinguished Young Scholars of China (51525207), National Natural Science Foundation of China (31570973), and Shanghai Committee of Science and Technology, China (15441904900, 14XD1403900) are acknowledged.
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/25035]
专题	中国科学院上海硅酸盐研究所
作者单位	1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Intervent Ctr, Shanghai 200438, Peoples R China
推荐引用方式 GB/T 7714	Wang, Donghui,Ge, Naijian,Yang, Tingting,et al. NIR-Triggered Crystal Phase Transformation of NiTi-Layered Double Hydroxides Films for Localized Chemothermal Tumor Therapy[J]. ADVANCED SCIENCE,2018,5(4).
APA	Wang, Donghui.,Ge, Naijian.,Yang, Tingting.,Peng, Feng.,Qiao, Yuqin.,...&Liu, Xuanyong.(2018).NIR-Triggered Crystal Phase Transformation of NiTi-Layered Double Hydroxides Films for Localized Chemothermal Tumor Therapy.ADVANCED SCIENCE,5(4).
MLA	Wang, Donghui,et al."NIR-Triggered Crystal Phase Transformation of NiTi-Layered Double Hydroxides Films for Localized Chemothermal Tumor Therapy".ADVANCED SCIENCE 5.4(2018).