3D printing of high-strength bioscaffolds for the synergistic treatment of bone cancer

doi:10.1038/s41427-018-0015-8

	3D printing of high-strength bioscaffolds for the synergistic treatment of bone cancer
	Ma, Hongshi 1; Li, Tao 2; Huan, Zhiguang ; Zhang, Meng ; Yang, Zezheng 2; Wang, Jinwu 2; Chang, Jiang ; Wu, Chengtie
刊名	NPG ASIA MATERIALS
	2018
卷号	10 页码:31
ISSN号	1884-4049
DOI	10.1038/s41427-018-0015-8
英文摘要	The challenges in bone tumor therapy are how to repair the large bone defects induced by surgery and kill all possible residual tumor cells. Compared to cancellous bone defect regeneration, cortical bone defect regeneration has a higher demand for bone substitute materials. To the best of our knowledge, there are currently few bifunctional biomaterials with an ultra-high strength for both tumor therapy and cortical bone regeneration. Here, we designed Fe-CaSiO3 composite scaffolds (30CS) via 3D printing technique. First, the 30CS composite scaffolds possessed a high compressive strength that provided sufficient mechanical support in bone cortical defects; second, synergistic photothermal and ROS therapies achieved an enhanced tumor therapeutic effect in vitro and in vivo. Finally, the presence of CaSiO3 in the composite scaffolds improved the degradation performance, stimulated the proliferation and differentiation of rBMSCs, and further promoted bone formation in vivo. Such 30CS scaffolds with a high compressive strength can function as versatile and efficient biomaterials for the future regeneration of cortical bone defects and the treatment of bone cancer.
学科主题	Materials Science, Multidisciplinary
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000438887500001
资助机构	This work was supported by the National Key Research and Development Program of China (2016YFB0700803), the Natural Science Foundation of China (81771989, 81401529, 81572156), the Key Research Program of Frontier Sciences CAS (QYZDB-SSW-SYS027), the Science and Technology Commission of Shanghai Municipality (17441903700, 16DZ2260603, 17540712300), the Key Research Program of Science and Technology Support Program of Jiangsu Province (BE2016763), and the Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support (20152224). ; This work was supported by the National Key Research and Development Program of China (2016YFB0700803), the Natural Science Foundation of China (81771989, 81401529, 81572156), the Key Research Program of Frontier Sciences CAS (QYZDB-SSW-SYS027), the Science and Technology Commission of Shanghai Municipality (17441903700, 16DZ2260603, 17540712300), the Key Research Program of Science and Technology Support Program of Jiangsu Province (BE2016763), and the Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support (20152224).
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/25012]
专题	中国科学院上海硅酸盐研究所
作者单位	1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100043, Peoples R China 3.Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Orthopaed Surg, Shanghai Key Lab Orthopaed Implant,Sch Med, Shanghai 200011, Peoples R China
推荐引用方式 GB/T 7714	Ma, Hongshi,Li, Tao,Huan, Zhiguang,et al. 3D printing of high-strength bioscaffolds for the synergistic treatment of bone cancer[J]. NPG ASIA MATERIALS,2018,10:31, 44.
APA	Ma, Hongshi.,Li, Tao.,Huan, Zhiguang.,Zhang, Meng.,Yang, Zezheng.,...&Wu, Chengtie.(2018).3D printing of high-strength bioscaffolds for the synergistic treatment of bone cancer.NPG ASIA MATERIALS,10,31.
MLA	Ma, Hongshi,et al."3D printing of high-strength bioscaffolds for the synergistic treatment of bone cancer".NPG ASIA MATERIALS 10(2018):31.