Graphene oxide as a dual Zn/Mg ion carrier and release platform: enhanced osteogenic activity and antibacterial properties

doi:10.1039/c8tb00162f

	Graphene oxide as a dual Zn/Mg ion carrier and release platform: enhanced osteogenic activity and antibacterial properties
	Qiu, Jiajun 1; Liu, Lu 2; Chen, Baohui 1; Qiao, Yuqin ; Cao, Huiliang ; Zhu, Hongqin ; Liu, Xuanyong
刊名	JOURNAL OF MATERIALS CHEMISTRY B
	2018
卷号	6 期号:13 页码:2004
ISSN号	2050-750X
DOI	10.1039/c8tb00162f
英文摘要	Implant failure of titanium and its alloys still occurs due to insufficient osseointegration and implant associated infections. Therefore, titanium implants with enhanced osseointegration and antibacterial activities are desirable. To achieve this goal, graphene oxide (GO) as a dual zinc/magnesium (Zn/Mg) ion carrier and release platform was constructed on the titanium surface by cathode electrophoresis deposition. Rat bone mesenchymal stem cells were used to investigate the osteogenic activity. Gram-negative E. coli was utilized to assess the antibacterial activities. Results show that GO co-doped with Mg and Zn ions with a sustained and slow release exhibited the best osteogenic activity among all the samples by stimulating the expressions of osteogenesis related genes containing alkaline phosphatase (ALP), type I collagen (Col-I), osteocalcin (OCN), and osteopontin (OPN), and by promoting the alkaline phosphatase activity and extracellular matrix mineralization. The existence of GO endowed titanium with superior antibacterial activities against Gram-negative E. coli. Due to the synergistic effects of GO, Mg and Zn ions, a titanium surface with enhanced osseointegration and antibacterial activities was achieved.
学科主题	Materials Science, bioMaterials
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000428777600014
资助机构	Financial support from the National Key Research and Development Program of China (2016YFC1100604), the National Science Foundation for Distinguished Young Scholars of China (51525207), the National Natural Science Foundation of China (31670980, 31570973), Shanghai Committee of Science and Technology, China (17441904000, 15441904900) are acknowledged. ; Financial support from the National Key Research and Development Program of China (2016YFC1100604), the National Science Foundation for Distinguished Young Scholars of China (51525207), the National Natural Science Foundation of China (31670980, 31570973), Shanghai Committee of Science and Technology, China (17441904000, 15441904900) are acknowledged.
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/25008]
专题	中国科学院上海硅酸盐研究所
作者单位	1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Shanghai Normal Univ, Shanghai 200234, Peoples R China
推荐引用方式 GB/T 7714	Qiu, Jiajun,Liu, Lu,Chen, Baohui,et al. Graphene oxide as a dual Zn/Mg ion carrier and release platform: enhanced osteogenic activity and antibacterial properties[J]. JOURNAL OF MATERIALS CHEMISTRY B,2018,6(13):2004, 2012.
APA	Qiu, Jiajun.,Liu, Lu.,Chen, Baohui.,Qiao, Yuqin.,Cao, Huiliang.,...&Liu, Xuanyong.(2018).Graphene oxide as a dual Zn/Mg ion carrier and release platform: enhanced osteogenic activity and antibacterial properties.JOURNAL OF MATERIALS CHEMISTRY B,6(13),2004.
MLA	Qiu, Jiajun,et al."Graphene oxide as a dual Zn/Mg ion carrier and release platform: enhanced osteogenic activity and antibacterial properties".JOURNAL OF MATERIALS CHEMISTRY B 6.13(2018):2004.