Perfluorooctyl bromide & indocyanine green co-loaded nanoliposomes for enhanced multimodal imaging-guided phototherapy

doi:10.1016/j.biomaterials.2018.02.041

	Perfluorooctyl bromide & indocyanine green co-loaded nanoliposomes for enhanced multimodal imaging-guided phototherapy
	Sheng, Danli ; Liu, Tianzhi 1; Deng, Liming ; Zhang, Liang ; Li, Xuelin ; Xu, Jie ; Hao, Lan ; Li, Pan ; Ran, Haitao ; Chen, Hangrong 1
刊名	BIOMATERIALS
	2018
卷号	165 页码:1
关键词	Indocyanine Green (ICG) Perfluorooctyl bromide (PFOB) Liposomes Multi-mode imaging Photodynamic therapy (PDT) Photothermal therapy (PTT)
ISSN号	0142-9612
DOI	10.1016/j.biomaterials.2018.02.041
英文摘要	As a highly biocompatible NIR dye, indocyanine green (ICG) has been widely explored for cancer treatment due to its various energy level transition pathways upon NIR light excitation simultaneously, which leads to different theranostic effects (eg. Photoacoustic (PA) and fluorescence imaging (FL), photodynamic and photothermal therapy (PDT&PTT)). However, the theranostic efficiency of ICG is restricted intrinsically, owing to the competitive relationship of its co-existing imaging and therapeutic effect. Moreover, the extrinsic hypoxia nature of tumor further limits its therapeutic effect, especially for the oxygen-dependent PDT. Herein, perfluorooctyl bromide (PFOB), another biocompatible chemical, was integrated with ICG in a nanoliposome structure via a facile two-step emulsion method. Such an ICG&PFOB co-loaded nanoliposomes (LIP-PFOB-ICG) realized computed tomography (CT) contrast imaging in vivo, providing better anatomical information of tumor in comparison to ICG enabled PA and FL imaging. More importantly, LIP-PFOB-ICG inhibited MDA-MB-231 tumor growth completely via intravenous injection through enhanced PDT&PTT synergistic therapy due to the excellent oxygen carrying ability of PFOB, which effectively attenuated tumor hypoxia, improved the efficiency of collisional energy transfer between ICG and oxygen and reduced the expression of heat shock protein (HSP). As expected, the introduction of PFOB within nanoliposomes with ICG has augmented the theranostic effect of ICG comprehensively, which makes this simple biocompatible liposome-based nanoagent a potential candidate for clinical imaging guided phototherapy of cancer. (C) 2018 Elsevier Ltd. All rights reserved.
学科主题	Engineering, Biomedical ; Materials Science, bioMaterials
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000429757500001
资助机构	This work as financially supported by the National Natural Science Foundation of China (Grant No. 31630026, 81771845, 81630047, 81771847, 81501482) and Chongqing foundation and cutting-edge research projects (Grant NO. cstc2016jcyjA0156). ; This work as financially supported by the National Natural Science Foundation of China (Grant No. 31630026, 81771845, 81630047, 81771847, 81501482) and Chongqing foundation and cutting-edge research projects (Grant NO. cstc2016jcyjA0156).
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/24952]
专题	中国科学院上海硅酸盐研究所
作者单位	1.Chongqing Med Univ, Affiliated Hosp 2, Inst Ultrasound Imaging, Chongqing 400010, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China
推荐引用方式 GB/T 7714	Sheng, Danli,Liu, Tianzhi,Deng, Liming,et al. Perfluorooctyl bromide & indocyanine green co-loaded nanoliposomes for enhanced multimodal imaging-guided phototherapy[J]. BIOMATERIALS,2018,165:1, 13.
APA	Sheng, Danli.,Liu, Tianzhi.,Deng, Liming.,Zhang, Liang.,Li, Xuelin.,...&Wang, Zhigang.(2018).Perfluorooctyl bromide & indocyanine green co-loaded nanoliposomes for enhanced multimodal imaging-guided phototherapy.BIOMATERIALS,165,1.
MLA	Sheng, Danli,et al."Perfluorooctyl bromide & indocyanine green co-loaded nanoliposomes for enhanced multimodal imaging-guided phototherapy".BIOMATERIALS 165(2018):1.