Bone tissue engineering strategy based on the synergistic effects of silicon and strontium ions

doi:10.1016/j.actbio.2018.03.051

	Bone tissue engineering strategy based on the synergistic effects of silicon and strontium ions
	Xing, Min 1; Wang, Xiaoya ; Wang, Endian 1; Gao, Long 1; Chang, Jiang
刊名	ACTA BIOMATERIALIA
	2018
卷号	72 页码:381
关键词	Synergistic effects Cell proliferation Sternness maintenance Osteogenic differentiation Bone tissue engineering
ISSN号	1742-7061
DOI	10.1016/j.actbio.2018.03.051
英文摘要	Multipotent human bone marrow mesenchymal stem cells (hBMSCs) are commonly used as seed cells in bone tissue engineering, but their clinical application is limited due to two challenges. One is the expansion of hBMSCs without loss of the sternness, and the other is the stimulation of osteogenic differentiation of hBMSCs when combined with biomaterials. In this study we demonstrated an approach by firstly elucidating the functional effects and optimal concentrations of Si and Sr ions on the proliferation and osteogenic differentiation of hBMSCs, and then designing bioactive bioceramic/alginate hydrogels which could release Si and Sr bioactive ions in the same optimal concentrations range for activation of the cells in vivo. The results showed that Si and Sr ions could synergistically stimulate cell proliferation without losing the sternness. Furthermore, at higher concentrations, Si and Sr ions stimulated osteogenic differentiation instead of enhancing proliferation. The designed bioactive hydrogels revealed activity to stimulate not only the osteogenic differentiation of encapsulated hBMSCs, but also the blood vessel formation in vivo. These results suggested that the design of biomaterials based on the biological function of different material elements was an effective approach for bone tissue engineering applications. Statement of Significance The clinical application of multipotent human bone marrow mesenchymal stem cells (hBMSCs) in bone tissue engineering is limited due to two challenges. One is the expansion of cells without loss of the sternness, and the other is the stimulation of osteogenic differentiation of hBMSCs within the biomaterial scaffolds. Herein, we demonstrated an approach by firstly elucidating the functional effects and optimal concentrations of Si and Sr ions on the proliferation without losing sternness and osteogenic differentiation of hBMSCs, and then designing a bioactive bioceramicialginate hydrogel which could release Si and Sr ions for in vivo activation of cells. The bioactive hydrogels revealed activity to stimulate not only osteogenic differentiation of encapsulated hBMSCs, but also the blood vessel formation in vivo. Our work provided an effective approach to design effective biomaterials for tissue engineering. (C) 2018 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
学科主题	Engineering, Biomedical ; Materials Science, bioMaterials
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000432766900033
资助机构	The authors gratefully acknowledge the financial support from the National Key Research Program of China (Grant No. 2016YFC1100201), the National Natural Science Foundation of China (Grant No. 81430012), and the International S&T Cooperation Project of Shanghai S&T Innovation Action Plan (Grant No.:17540712300). ; The authors gratefully acknowledge the financial support from the National Key Research Program of China (Grant No. 2016YFC1100201), the National Natural Science Foundation of China (Grant No. 81430012), and the International S&T Cooperation Project of Shanghai S&T Innovation Action Plan (Grant No.:17540712300).
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/24944]
专题	中国科学院上海硅酸盐研究所
作者单位	1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, 1295 Dingxi Rd, Shanghai 200050, Peoples R China 2.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Xing, Min,Wang, Xiaoya,Wang, Endian,et al. Bone tissue engineering strategy based on the synergistic effects of silicon and strontium ions[J]. ACTA BIOMATERIALIA,2018,72:381, 395.
APA	Xing, Min,Wang, Xiaoya,Wang, Endian,Gao, Long,&Chang, Jiang.(2018).Bone tissue engineering strategy based on the synergistic effects of silicon and strontium ions.ACTA BIOMATERIALIA,72,381.
MLA	Xing, Min,et al."Bone tissue engineering strategy based on the synergistic effects of silicon and strontium ions".ACTA BIOMATERIALIA 72(2018):381.