Prussian Blue Nanozyme with Multienzyme Activity Reduces Colitis in Mice

doi:10.1021/acsami.8b10345

	Prussian Blue Nanozyme with Multienzyme Activity Reduces Colitis in Mice
	Zhao, Jiulong ; Cai, Xiaojun 1,2; Gao, Wei 2; Zhang, Linlin 1; Zou, Duowu ; Zheng, Yuanyi 2; Li, Zhaoshen ; Chen, Hangrong 1
刊名	ACS APPLIED MATERIALS & INTERFACES
	2018
卷号	10 期号:31 页码:26108
关键词	Prussian blue reactive oxygen species inflammatory bowel disease colitis nanozyme
ISSN号	1944-8244
DOI	10.1021/acsami.8b10345
英文摘要	The overproduction of reactive oxygen species (ROS) is central to the progression of inflammatory bowel disease (IBD), which may be the potential therapeutic target. Prussian blue (PB) nanoparticles with good biosafety can act as an artificial nanozyme, effectively scavenging ROS. To date, PB-based nanomaterials have not been developed and utilized for treatment of IBD. In this study, poly(vinylpyrrolidone)-modified Prussian blue (PPB) nanoparticles are constructed with good physiological stability and biosafety by a simple and efficient method. The prepared PPBs with capabilities of scavenging ROS and inhibiting proinflammatory cytokine significantly reduce colitis in mice without distinct side effects via intravenous administration. This report provides a demonstration of the protective effect of PB-based nanomedicine against IBD in living animals, offering hope and a potential alternative treatment option for patients suffering from IBD.
学科主题	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000441477800031
资助机构	This work was supported by the National Natural Science Foundation of China (Grant Nos. 81470800, 51772316, 81670485, and 81370493), the National Key Research and Development Program of China (Grant No. 2017YFB0702602), the Key Projects of International Cooperation and Exchanges of NSFC (No. 81720108023), and the Interdisciplinary Program of Shanghai Jiao Tong University (No. YG2017QN20). ; This work was supported by the National Natural Science Foundation of China (Grant Nos. 81470800, 51772316, 81670485, and 81370493), the National Key Research and Development Program of China (Grant No. 2017YFB0702602), the Key Projects of International Cooperation and Exchanges of NSFC (No. 81720108023), and the Interdisciplinary Program of Shanghai Jiao Tong University (No. YG2017QN20).
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/24738]
专题	中国科学院上海硅酸盐研究所
作者单位	1.Second Mil Med Univ, Changhai Hosp, Dept Gastroenterol, Shanghai 200433, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 3.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Shanghai Inst Ultrasound Med, Shanghai 200050, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Jiulong,Cai, Xiaojun,Gao, Wei,et al. Prussian Blue Nanozyme with Multienzyme Activity Reduces Colitis in Mice[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(31):26108, 26117.
APA	Zhao, Jiulong.,Cai, Xiaojun.,Gao, Wei.,Zhang, Linlin.,Zou, Duowu.,...&Chen, Hangrong.(2018).Prussian Blue Nanozyme with Multienzyme Activity Reduces Colitis in Mice.ACS APPLIED MATERIALS & INTERFACES,10(31),26108.
MLA	Zhao, Jiulong,et al."Prussian Blue Nanozyme with Multienzyme Activity Reduces Colitis in Mice".ACS APPLIED MATERIALS & INTERFACES 10.31(2018):26108.