In situ modulation of crystallinity and nano-structures to enhance the stability and osseointegration of hydroxyapatite coatings on Ti-6Al-4V implants

doi:10.1016/j.cej.2018.04.045

	In situ modulation of crystallinity and nano-structures to enhance the stability and osseointegration of hydroxyapatite coatings on Ti-6Al-4V implants
	Xia, Lunguo ; Xie, Youtao 1; Fang, Bing ; Wang, Xiuhui 1; Lin, Kaili 2
刊名	CHEMICAL ENGINEERING JOURNAL
	2018
卷号	347 页码:711
关键词	Bioactive hydroxyapatite coatings In situ modulation Nano-structure Stability Osteogenic differentiation Osseointegration
ISSN号	1385-8947
DOI	10.1016/j.cej.2018.04.045
英文摘要	Maintaining the high crystallinity and tailoring the nano-structured surface of hydroxyapatite (HA) coatings on Ti-6Al-4V implants play critical roles in realizing their long-term service life span and fast osseointegration for biomedical implants. Herein, a nanorod structured HA (nHA) coating with a pure phase and high crystallinity was successfully developed by combining atmospheric plasma spraying (APS) with hydrothermal treatment (HT). The crystallinity degree of the plasma-sprayed HA coating was increased from 51.3% to over 85.3% by hydrothermal treatment, which meets the medical device industrial standard of having a crystallinity no less than 62% and significantly decreased the degradation rate of the HA coating. In addition, the construction of a nanorod structured surface promoted the attachment, proliferation and differentiation of rat bone mesenchymal stem cell (rBMSCs), thus further improving the osseointegration between implants and the surrounding bone tissue. Hence, the stable and bioactive nHA-coated Ti-6Al-4V implant has considerable potential in dental and orthopedic applications.
学科主题	Engineering, Environmental ; Engineering, Chemical
出版者	ELSEVIER SCIENCE SA
WOS记录号	WOS:000432884900070
资助机构	The authors gratefully acknowledge the support of Natural Science Foundation of China (81672134, 81771115, 81400554), Science and Technology Commission of Shanghai Municipality (17510710800), the Fund of Shanghai Municipal Commission of Health and Family Planning (201540369), Municipal Human Resources Development Program for Outstanding Young Talents in Medical and Health Sciences in Shanghai (2017YQ058), Excellent Youth Program of Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (jyyq08201621). ; The authors gratefully acknowledge the support of Natural Science Foundation of China (81672134, 81771115, 81400554), Science and Technology Commission of Shanghai Municipality (17510710800), the Fund of Shanghai Municipal Commission of Health and Family Planning (201540369), Municipal Human Resources Development Program for Outstanding Young Talents in Medical and Health Sciences in Shanghai (2017YQ058), Excellent Youth Program of Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (jyyq08201621).
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/24706]
专题	中国科学院上海硅酸盐研究所
作者单位	1.Shanghai Jiao Tong Univ, Sch Med, Peoples Hosp 9, Dept Orthodont,Collage Stomatol, Shanghai 200011, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Ceram, Shanghai 200050, Peoples R China 3.Shanghai Jiao Tong Univ, Shanghai Res Inst Stomatol, Dept Oral & Craniomaxillofacial Surg,Sch Med, Shanghai Key Lab Stomatol,Shanghai Peoples Hosp 9, Shanghai 200011, Peoples R China
推荐引用方式 GB/T 7714	Xia, Lunguo,Xie, Youtao,Fang, Bing,et al. In situ modulation of crystallinity and nano-structures to enhance the stability and osseointegration of hydroxyapatite coatings on Ti-6Al-4V implants[J]. CHEMICAL ENGINEERING JOURNAL,2018,347:711, 720.
APA	Xia, Lunguo,Xie, Youtao,Fang, Bing,Wang, Xiuhui,&Lin, Kaili.(2018).In situ modulation of crystallinity and nano-structures to enhance the stability and osseointegration of hydroxyapatite coatings on Ti-6Al-4V implants.CHEMICAL ENGINEERING JOURNAL,347,711.
MLA	Xia, Lunguo,et al."In situ modulation of crystallinity and nano-structures to enhance the stability and osseointegration of hydroxyapatite coatings on Ti-6Al-4V implants".CHEMICAL ENGINEERING JOURNAL 347(2018):711.