Biodegradable nanocomposite of glycerol citrate polyester and ultralong hydroxyapatite nanowires with improved mechanical properties and low acidity

doi:10.1016/j.jcis.2018.06.059

	Biodegradable nanocomposite of glycerol citrate polyester and ultralong hydroxyapatite nanowires with improved mechanical properties and low acidity
	Shen, Yue-Qin ; Zhu, Ying-Jie ; Yu, Han-Ping ; Lu, Bing-Qiang
刊名	JOURNAL OF COLLOID AND INTERFACE SCIENCE
	2018
卷号	530 页码:9
关键词	Hydroxyapatite Nanowires Nanocomposite Glycerol citrate polyester Solvothermal
ISSN号	0021-9797
DOI	10.1016/j.jcis.2018.06.059
英文摘要	Glycerol citrate polyester based on the condensation of glycerol and citric acid has a great potential in biomedical applications owing to biocompatible monomers and biodegradation properties. However, the applications of glycerol citrate polyester are impaired by its poor mechanical properties and high acidity caused by citric acid produced in the degradation process. In this work, a new kind of nanocomposite has been developed using ultralong hydroxyapatite (HAP) nanowires as the "skeleton", and strongly bound glycerol citrate polyester as the "muscle". The ultralong HAP nanowires interweave with each other to form a three-dimensional nanoporous network, and glycerol citrate polyester is homogeneously distributed in the nanoporous network. Owing to the reinforcement of ultralong HAP nanowires, the mechanical properties of the as-prepared nanocomposite are significantly improved compared with the pure glycerol citrate polyester, and the tensile strength even reaches to the level of human cortical bones. Furthermore, the acidity of the aqueous solution after degradation is neutralized by the reaction between citric acid and ultralong HAP nanowires, and the pH value can be stabilized. The as-prepared nanocomposite can solve some problems of the pure glycerol citrate polyester, and shows promising applications in the biomedical field. (C) 2018 Elsevier Inc. All rights reserved.
学科主题	Chemistry, Physical
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号	WOS:000442700000002
资助机构	The financial support from the National Natural Science Foundation of China (21501188), and the Science and Technology Commission of Shanghai Municipality (15JC1491001) is gratefully acknowledged. ; The financial support from the National Natural Science Foundation of China (21501188), and the Science and Technology Commission of Shanghai Municipality (15JC1491001) is gratefully acknowledged.
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/24630]
专题	中国科学院上海硅酸盐研究所
作者单位	1.[Zhu, Ying-Jie 2.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Shen, Yue-Qin,Zhu, Ying-Jie,Yu, Han-Ping,et al. Biodegradable nanocomposite of glycerol citrate polyester and ultralong hydroxyapatite nanowires with improved mechanical properties and low acidity[J]. JOURNAL OF COLLOID AND INTERFACE SCIENCE,2018,530:9, 15.
APA	Shen, Yue-Qin,Zhu, Ying-Jie,Yu, Han-Ping,&Lu, Bing-Qiang.(2018).Biodegradable nanocomposite of glycerol citrate polyester and ultralong hydroxyapatite nanowires with improved mechanical properties and low acidity.JOURNAL OF COLLOID AND INTERFACE SCIENCE,530,9.
MLA	Shen, Yue-Qin,et al."Biodegradable nanocomposite of glycerol citrate polyester and ultralong hydroxyapatite nanowires with improved mechanical properties and low acidity".JOURNAL OF COLLOID AND INTERFACE SCIENCE 530(2018):9.