A pH and magnetic dual-response hydrogel for synergistic chemo-magnetic hyperthermia tumor therapy

doi:10.1039/c8ra00215k

	A pH and magnetic dual-response hydrogel for synergistic chemo-magnetic hyperthermia tumor therapy
	Zhou, Xiaohan ; Wang, Longchen 1; Xu, Yanjun 1; Du, Wenxian 2; Cai, Xiaojun 1; Wang, Fengjuan ; Ling, Yi 1; Chen, Hangrong 2; Wang, Zhigang ; Hu, Bing 1
刊名	RSC ADVANCES
	2018
卷号	8 期号:18 页码:9812
ISSN号	2046-2069
DOI	10.1039/c8ra00215k
英文摘要	To overcome the toxicity of chemotherapy, increasing attention has been paid to local drug delivery systems (DDSs). pH-Sensitive hydrogels have emerged as promising DDS materials in the biomedical field due to their remarkable characteristics. However, the pH environment in tumor varies from person to person, which makes the applicability of systems based on pH challenging. In this study, we developed a contractible hydroxypropyl methyl cellulose (HPMC)/Fe3O4 hydrogel with dual-response pH and magnetic properties aiming to overcome the limitations of pH-sensitive hydrogel drug delivery systems and further increase their efficiency in tumor therapy. The HPMC/Fe3O4 hydrogel could act as a drug delivery system that combines pH-sensitive triggering and magnetic dual-response drug release for synergistic chemo-magnetic hyperthermia therapy. The drug delivery profile of the HPMC/Fe3O4/ doxorubicin hydrochloride (DOX) hydrogel was determined in vitro and revealed a remarkable pH-sensitive performance. After synergistic chemo-magnetic hyperthermia treatment, mice with 4T1 breast cancer xenografts recovered without any recurrence or metastasis, demonstrating the synergistic effect of chemotherapy and magnetic hyperthermia therapy. Meanwhile, reduced toxicity and superior anticancer effects were achieved due to the combined effect of the pH and magnetic hyperthermia response properties. This study demonstrated the high efficacy and low toxicity of the improved design of HPMC/Fe3O4 for drug delivery, which may provide a promising approach for the application of chemo-magnetic hyperthermia cancer therapy.
学科主题	Chemistry, Multidisciplinary
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000430451800028
资助机构	The authors thank Prof. Yaopeng Zhang from DongHua University for help with this study. We acknowledge financial support from 973 project (2014CB744500), the National Science Foundation for Distinguished Young Scholars (NO. 81425014), the National Natural Science of China (NO. 81720108023, 31630026), and Shanghai Key Discipline of Medical Imaging (2017ZZ02005). ; The authors thank Prof. Yaopeng Zhang from DongHua University for help with this study. We acknowledge financial support from 973 project (2014CB744500), the National Science Foundation for Distinguished Young Scholars (NO. 81425014), the National Natural Science of China (NO. 81720108023, 31630026), and Shanghai Key Discipline of Medical Imaging (2017ZZ02005).
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/24577]
专题	中国科学院上海硅酸盐研究所
作者单位	1.Chongqing Med Univ, Affiliated Hosp 2, State Key Lab Ultrasound Engn Med Cofounded Chong, Chongqing Key Lab Ultrasound Mol Imaging,Minist S, Chongqing 400010, Peoples R China 2.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Shanghai 200233, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Xiaohan,Wang, Longchen,Xu, Yanjun,et al. A pH and magnetic dual-response hydrogel for synergistic chemo-magnetic hyperthermia tumor therapy[J]. RSC ADVANCES,2018,8(18):9812, 9821.
APA	Zhou, Xiaohan.,Wang, Longchen.,Xu, Yanjun.,Du, Wenxian.,Cai, Xiaojun.,...&Zheng, Yuanyi.(2018).A pH and magnetic dual-response hydrogel for synergistic chemo-magnetic hyperthermia tumor therapy.RSC ADVANCES,8(18),9812.
MLA	Zhou, Xiaohan,et al."A pH and magnetic dual-response hydrogel for synergistic chemo-magnetic hyperthermia tumor therapy".RSC ADVANCES 8.18(2018):9812.