Comparative study of nanostructured carriers of calcium phosphate and magnesium phosphate loaded with SRT1720 for the protection of H2O2-induced senescent endothelium

	Comparative study of nanostructured carriers of calcium phosphate and magnesium phosphate loaded with SRT1720 for the protection of H2O2-induced senescent endothelium
	Su, Zhi-Xiao ; Shi, Yi-Qin ; Lu, Zhao-Yang ; Li, Rui-Lin ; Wang, Xue-Lian ; Ning, Bing-Bing ; Duan, Jun-Li ; Hao, Liang-Shi ; Duan, Jun-Hui ; Li, Yue 4
刊名	AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
	2018
卷号	10 期号:7 页码:2068
关键词	Nanostucture calcium phosphate magnesium phosphate SRT1720 endothelial cell senescence
ISSN号	1943-8141
英文摘要	Nanostructured calcium phosphate (CaP) and magnesium phosphate (MgP) are promising for the application as the nanocarriers in drug delivery. However, the difference between CaP and MgP nanocarriers in drug delivery is rarely investigated. In this work, we comparatively investigated nanostructured CaP, MgP and calcium magnesium phosphate (CMP) for the delivery of SRT1720, which is a silent information regulator (SIRT1) specific activator with pro-angiogenic and anti-aging properties in response to hydrogen peroxide (H2O2)-induced endothelial senescence. The protection of SRT1720-loaded CaP nanospheres, MgP nanosheets and CMP microspheres on the H2O2-induced senescent endothelium was examined by using human umbilical vein endothelial cells (HUVECs), demonstrating the improved cell viability, anti-aging, tube formation and migration. In addition, the SRT1720-loaded CaP nanospheres, MgP nanosheets and CMP microspheres can rescue the impaired angiogenic potential of HUVECs via activation of Akt/eNOS/VEGF pathway. The SRT1720-loaded MgP nanosheets and CMP microspheres have a similar protective effect compared with the pure SRT1720, while the SRT1720-loaded CaP nanospheres decrease the protective capability of SRT1720. These results lead us to figure out both MgP nanosheets and CMP microspheres are suitable and effective delivery for SRT1720 and this system can be further applied in vivo treatment.
学科主题	Oncology ; Medicine, Research & Experimental
出版者	E-CENTURY PUBLISHING CORP
WOS记录号	WOS:000440066200012
资助机构	This work was supported by the the Opening Project of Shanghai Key Laboratory of New Durg Design (17DZ2271000), China National Natural Science Foundation (11374213, 11574210, 81500523 and 81500372) and Funding for Clinical Trial of Xinhua Hospital (DJL). ; This work was supported by the the Opening Project of Shanghai Key Laboratory of New Durg Design (17DZ2271000), China National Natural Science Foundation (11374213, 11574210, 81500523 and 81500372) and Funding for Clinical Trial of Xinhua Hospital (DJL).
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/24566]
专题	中国科学院上海硅酸盐研究所
作者单位	1.East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Meilong Rd 130, Shanghai 200237, Peoples R China 2.Shanghai Jiao Tong Univ, Xinhua Hosp, Sch Med, Clin Res Unit, Kongjiang Rd 1665, Shanghai 200092, Peoples R China 3.Fudan Univ, Zhongshan Hosp, Dept Nephrol, Fenglin Rd 180, Shanghai 200032, Peoples R China 4.Tongji Univ, Peoples Hosp 10, Dept Cardiol, Yanchang Rd 301, Shanghai 200072, Peoples R China 5.Univ Maryland, Div Pulm & Crit Care Med, Dept Med, Sch Med, 20 Penn St,HSF-2,Room S112, Baltimore, MD 21201 USA 6.Chinese Acad Sci, State Key Lab High Performance Ceram & Superfine, Shanghai Inst Ceram, Shanghai 200050, Peoples R China
推荐引用方式 GB/T 7714	Su, Zhi-Xiao,Shi, Yi-Qin,Lu, Zhao-Yang,et al. Comparative study of nanostructured carriers of calcium phosphate and magnesium phosphate loaded with SRT1720 for the protection of H2O2-induced senescent endothelium[J]. AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH,2018,10(7):2068, 2077.
APA	Su, Zhi-Xiao.,Shi, Yi-Qin.,Lu, Zhao-Yang.,Li, Rui-Lin.,Wang, Xue-Lian.,...&Wang, Rui.(2018).Comparative study of nanostructured carriers of calcium phosphate and magnesium phosphate loaded with SRT1720 for the protection of H2O2-induced senescent endothelium.AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH,10(7),2068.
MLA	Su, Zhi-Xiao,et al."Comparative study of nanostructured carriers of calcium phosphate and magnesium phosphate loaded with SRT1720 for the protection of H2O2-induced senescent endothelium".AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH 10.7(2018):2068.