Synthesis of artificial dental enamel by an elastin-like polypeptide assisted biomimetic approach

doi:10.1039/c7tb02576a

	Synthesis of artificial dental enamel by an elastin-like polypeptide assisted biomimetic approach
	Zhou, Yang 1; Zhou, Yanling ; Gao, Long 1; Wu, Chengtie ; Chang, Jiang
刊名	JOURNAL OF MATERIALS CHEMISTRY B
	2018
卷号	6 期号:5 页码:844
ISSN号	2050-750X
DOI	10.1039/c7tb02576a
英文摘要	Teeth are important for our life, and enamel, as the outermost layer of the tooth, plays a key role in maintaining the function and health of the tooth. Regeneration of acid eroded enamel is a big challenge due to the lack of living cells in the enamel. Here, we propose a novel way to chemically synthesize the enamel structure by mimicking the interaction of amorphous calcium phosphate (ACP) and acidic proteins during the formation of natural enamel. The process includes the formation of ACP in situ by acid etching and then the formation of a Ca-rich polypeptide-ACP complex on acid etched enamel apatite crystals, the oriented nucleation and growth of apatite nano-crystals along the acid etched enamel apatite crystals, and infiltration of a regenerated enamel apatite structure with dental resin. The synthesized enamel reveals not only excellent mechanical properties, which are highly close to those of original natural enamel, but also reveals high chemical stability against acid erosion. This innovative method may create potential applications of the functional artificial enamel for repairing damaged tooth enamel.
学科主题	Materials Science, bioMaterials
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000423898100016
资助机构	This study was financially funded by the Natural Science Foundation of China (Grant 81430012 and 81190132), and the National Key R&D Program of China (Grant 2016YFC1100201). ; This study was financially funded by the Natural Science Foundation of China (Grant 81430012 and 81190132), and the National Key R&D Program of China (Grant 2016YFC1100201).
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/24498]
专题	中国科学院上海硅酸盐研究所
作者单位	1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, 1295 Dingxi Rd, Shanghai 200050, Peoples R China 2.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Yang,Zhou, Yanling,Gao, Long,et al. Synthesis of artificial dental enamel by an elastin-like polypeptide assisted biomimetic approach[J]. JOURNAL OF MATERIALS CHEMISTRY B,2018,6(5):844, 853.
APA	Zhou, Yang,Zhou, Yanling,Gao, Long,Wu, Chengtie,&Chang, Jiang.(2018).Synthesis of artificial dental enamel by an elastin-like polypeptide assisted biomimetic approach.JOURNAL OF MATERIALS CHEMISTRY B,6(5),844.
MLA	Zhou, Yang,et al."Synthesis of artificial dental enamel by an elastin-like polypeptide assisted biomimetic approach".JOURNAL OF MATERIALS CHEMISTRY B 6.5(2018):844.