Loading 5-Fluorouracil into calcined Mg/Al layered double hydroxide on AZ31 via memory effect

doi:10.1016/j.matlet.2017.11.007

	Loading 5-Fluorouracil into calcined Mg/Al layered double hydroxide on AZ31 via memory effect
	Peng, Feng 1; Wang, Donghui 1; Cao, Huiliang ; Liu, Xuanyon
刊名	MATERIALS LETTERS
	2018
卷号	213 页码:383
关键词	Biomaterials Functional Corrosion Surfaces Thin films
ISSN号	0167-577X
DOI	10.1016/j.matlet.2017.11.007
英文摘要	The clinic application of magnesium is mainly impeded by its poor corrosion resistance and implants with localized drug delivery attract tremendous interest. Here, Mg/Al layered double hydroxide (Mg-Al LDH) film was in situ prepared on AZ31 alloy by a hydrothermal process, and further calcined to form metastable mixed oxides, also named Mg/Al layered double oxide (LDO). Finally, immersing in 5Fluorouracil (5-FU) solution, Mg/Al LDO would revert to Mg/Al LDH via a memory effect, and be loaded with 5-FU (#LDO-5FU). Comparing to AZ31 alloy, the corrosion resistance of the as-prepared #LDO-5FU sample was enhanced. The amount of released 5-FU from # LDO-5FU sample was similar to 993 ng/cm(2). The proliferation of human cholangiocarcinoma cell (RBE) was effectively inhibited on the surface of # LDO-5FU sample owing to the release of 5-FU. This work broadens the application of calcined LDH and provides a new strategy in the field of surface modification of magnesium alloy. (C) 2017 Elsevier B.V. All rights reserved.
学科主题	Materials Science, Multidisciplinary ; Physics, Applied
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000419049300096
资助机构	This work is financially supported by National Natural Science Foundation of China (31771044, 31370962), the National Key Research and Development Program of China No. 2016YFC1100604, Shanghai Committee of Science and Technology, China (15441904900). ; This work is financially supported by National Natural Science Foundation of China (31771044, 31370962), the National Key Research and Development Program of China No. 2016YFC1100604, Shanghai Committee of Science and Technology, China (15441904900).
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/24482]
专题	中国科学院上海硅酸盐研究所
作者单位	1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Peng, Feng,Wang, Donghui,Cao, Huiliang,et al. Loading 5-Fluorouracil into calcined Mg/Al layered double hydroxide on AZ31 via memory effect[J]. MATERIALS LETTERS,2018,213:383, 386.
APA	Peng, Feng,Wang, Donghui,Cao, Huiliang,&Liu, Xuanyon.(2018).Loading 5-Fluorouracil into calcined Mg/Al layered double hydroxide on AZ31 via memory effect.MATERIALS LETTERS,213,383.
MLA	Peng, Feng,et al."Loading 5-Fluorouracil into calcined Mg/Al layered double hydroxide on AZ31 via memory effect".MATERIALS LETTERS 213(2018):383.