An autonomous tumor-targeted nanoprodrug for reactive oxygen species-activatable dual-cytochrome c/doxorubicin antitumor therapy

doi:10.1039/c8nr02358a

	An autonomous tumor-targeted nanoprodrug for reactive oxygen species-activatable dual-cytochrome c/doxorubicin antitumor therapy
	Pei, Yuxia 1; Li, Menghuan 2; Hou, Yanhua 3; Hu, Yan 1; Chu, Guangyu 4; Dai, Liangliang 1; Li, Ke 1; Xing, Yuxin 1; Tao, Bailong 1; Yu, Yonglin 1
刊名	NANOSCALE
	2018-06-28
卷号	10 期号:24 页码:11418-11429
ISSN号	2040-3364
DOI	10.1039/c8nr02358a
英文摘要	The precise tumor cell-specific delivery of therapeutic proteins and the elimination of side effects associated with routine chemotherapeutic agents are two current critical considerations for tumor therapy. In this study, we report a reactive oxygen species (ROS)-activated yolk-shell nanoplatform for the tumor-specific co-delivery of cytochrome c (Cyt c) prodrug and doxorubicin, in which the bioactivity of Cyt c could be restored by the intracellular ROS-trigger and readily initiate the sequential doxorubicin release. The DOX-loaded lactobionic acid-modified yolk-shell mesoporous silica nanoparticles were first encapsulated with 4-nitrophenyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl carbonate (NBC)-modified Cyt c via boronic ester linkages, and functionalized again with lactobionic acid to further shield Cyt c and confer the selective tumor targeting against liver cancer cells. The key feature in this design is that by taking advantage of the boronic ester linkage, the cytotoxicity of Cyt c capped on the nanoparticle could be temporarily deactivated during blood transportation and rapidly restored upon exposure to the ROS-rich microenvironment within liver cancer cells, thereby simultaneously achieving the protein therapy and stimuli-responsive doxorubicin release. This study presents a novel strategy for the development of tumor-sensitive co-delivery nanoplatforms.
资助项目	National Natural Science Foundation of China[51602034] ; National Natural Science Foundation of China[51603024] ; National Key R&D Program of China[2016YFC1100300] ; National Key R&D Program of China[2017YFB0702600] ; China Postdoctoral Science Foundation[2017M612919] ; Innovation Project of the Common Key Technology of Chongqing Science and Technology Industry[cstc2015zdcy-ztzx120003] ; People's Livelihood Special Innovation Projects of Chongqing CSTC[cstc2017shmsA1089] ; Fundamental Research Funds for the Central Universities[10611CDJXZ238826]
WOS关键词	MESOPOROUS SILICA NANOPARTICLES ; INTRACELLULAR PROTEIN DELIVERY ; CANCER-THERAPY ; HYDROGEN-PEROXIDE ; FLUORESCENT-PROBE ; DRUG-DELIVERY ; RELEASE ; PRODRUG ; NANOMEDICINE ; NANOCARRIERS
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000436133400022
资助机构	National Natural Science Foundation of China ; National Key R&D Program of China ; China Postdoctoral Science Foundation ; Innovation Project of the Common Key Technology of Chongqing Science and Technology Industry ; People's Livelihood Special Innovation Projects of Chongqing CSTC ; Fundamental Research Funds for the Central Universities
内容类型	期刊论文
源URL	[http://ir.qibebt.ac.cn/handle/337004/12337]
专题	中国科学院青岛生物能源与过程研究所
通讯作者	Hu, Yan; Luo, Zhong; Cai, Kaiyong
作者单位	1.Chongqing Univ, Coll Bioengn, Minist Educ, Key Lab Biorheol Sci & Technol, Chongqing 400044, Peoples R China 2.Chongqing Univ, Sch Life Sci, Chongqing 400044, Peoples R China 3.Chongqing Med & Pharmaceut Coll, Chongqing Engn Res Ctr Pharmaceut Sci, Chongqing 401331, Peoples R China 4.Chinese Acad Sci, Inst Acoust, Qingdao Branch, Qingdao, Peoples R China
推荐引用方式 GB/T 7714	Pei, Yuxia,Li, Menghuan,Hou, Yanhua,et al. An autonomous tumor-targeted nanoprodrug for reactive oxygen species-activatable dual-cytochrome c/doxorubicin antitumor therapy[J]. NANOSCALE,2018,10(24):11418-11429.
APA	Pei, Yuxia.,Li, Menghuan.,Hou, Yanhua.,Hu, Yan.,Chu, Guangyu.,...&Cai, Kaiyong.(2018).An autonomous tumor-targeted nanoprodrug for reactive oxygen species-activatable dual-cytochrome c/doxorubicin antitumor therapy.NANOSCALE,10(24),11418-11429.
MLA	Pei, Yuxia,et al."An autonomous tumor-targeted nanoprodrug for reactive oxygen species-activatable dual-cytochrome c/doxorubicin antitumor therapy".NANOSCALE 10.24(2018):11418-11429.