AbmV Catalyzes Tandem Ether Installation and Hydroxylation during Neoabyssomicin/Abyssomicin Biosynthesis

doi:10.1021/acs.orglett.8b01997

	AbmV Catalyzes Tandem Ether Installation and Hydroxylation during Neoabyssomicin/Abyssomicin Biosynthesis
	Li, Qinglian 1; Ding, Wenjuan 1,2; Yao, Ziwei 1,2; Tu, Jiajia 1; Wang, Liyan 3; Huang, Hongbo 1; Li, Shengying 4; Ju, Jianhua 1,2
刊名	ORGANIC LETTERS
	2018-08-17
卷号	20 期号:16 页码:4854-4857
ISSN号	1523-7060
DOI	10.1021/acs.orglett.8b01997
英文摘要	Members of the abyssomicin class of natural products are characterized by a novel vinylic bridged ether ring. In this study, in vivo gene inactivation, structure elucidation of the accumulated intermediate abyssomicin 6, and in vitro enzyme assays enabled the identification of a cytochrome P450 enzyme, AbmV. AbmV carries out domino reactions involving bridged ether installation and C-11 hydroxylation during the biosynthesis of neoabyssomicins/abyssomicins in S. koyangensis SCSIO 5802.
资助项目	China NSF[31670087] ; China NSF[81425022] ; China NSF[U1501223] ; China NSF[U1706206] ; China NSF[41476133] ; CAS[XDA11030403] ; CAS[XDA13020302-2] ; Guangdong NSF[2016A030312014] ; Pearl River S&T Nova Program of Guangzhou[201806010109] ; Special Support Program for Training High-Level Talents in Guangdong[2016TQ03R288]
WOS关键词	MARINE VERRUCOSISPORA STRAIN ; KOYANGENSIS SCSIO 5802 ; CYTOCHROME-P450 MONOOXYGENASE ; ABYSSOMICIN-C ; STREPTOMYCES ; P450 ; POLYKETIDE ; EXPRESSION ; AB-18-032 ; PATHWAY
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000442454900030
资助机构	China NSF ; CAS ; Guangdong NSF ; Pearl River S&T Nova Program of Guangzhou ; Special Support Program for Training High-Level Talents in Guangdong
内容类型	期刊论文
源URL	[http://ir.qibebt.ac.cn/handle/337004/11990]
专题	中国科学院青岛生物能源与过程研究所
通讯作者	Li, Qinglian; Ju, Jianhua
作者单位	1.Chinese Acad Sci, South China Sea Inst Oceanol, RNAM Ctr Marine Microbiol, CAS Key Lab Trop Marine Bioresources & Ecol,Guang, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China 2.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China 3.Shenzhen Univ, Coll Bio & Marine Sci, 3688 Nanhai Ave, Shenzhen 518060, Peoples R China 4.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Shandong Prov Key Lab Synthet Biol, CAS Key Lab Biofuels, Qingdao 266000, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Li, Qinglian,Ding, Wenjuan,Yao, Ziwei,et al. AbmV Catalyzes Tandem Ether Installation and Hydroxylation during Neoabyssomicin/Abyssomicin Biosynthesis[J]. ORGANIC LETTERS,2018,20(16):4854-4857.
APA	Li, Qinglian.,Ding, Wenjuan.,Yao, Ziwei.,Tu, Jiajia.,Wang, Liyan.,...&Ju, Jianhua.(2018).AbmV Catalyzes Tandem Ether Installation and Hydroxylation during Neoabyssomicin/Abyssomicin Biosynthesis.ORGANIC LETTERS,20(16),4854-4857.
MLA	Li, Qinglian,et al."AbmV Catalyzes Tandem Ether Installation and Hydroxylation during Neoabyssomicin/Abyssomicin Biosynthesis".ORGANIC LETTERS 20.16(2018):4854-4857.