Comparative Analysis of the Microbial Profiles in Supragingival Plaque Samples Obtained From Twins With Discordant Caries Phenotypes and Their Mothers

doi:10.3389/fcimb.2018.00361

	Comparative Analysis of the Microbial Profiles in Supragingival Plaque Samples Obtained From Twins With Discordant Caries Phenotypes and Their Mothers
	Zheng, Yuqiao 1; Zhang, Meng 1; Li, Jin 1; Li, Yuhong 1; Teng, Fei 2; Jiang, Han 1; Du, Minquan 1
刊名	FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
	2018-10-16
卷号	8 页码:13
关键词	early childhood caries supragingival plaque twins oral microbiome mother
ISSN号	2235-2988
DOI	10.3389/fcimb.2018.00361
英文摘要	Early childhood caries (ECC), the most frequent disease of oral cavity in preschool children, is the consequence of microbial, genetic, biochemical, socioeconomic, physical, environmental and health-influencing behavioral factors. To investigate the role of the oral microbiome and the impact of host and environmental factors in the occurrence and development of ECC, we studied the supragingival plaques of 14 twin pairs and a set of triplets with discordant caries phenotypes and 15 mothers, applying the Human Oral Microbe Identification using Next Generation Sequencing technique (HOMINGS). A total of 2,293,650 reads revealed 11 phyla, 116 genera, and 139 species of micromiome. Comparative analysis between the caries and caries-free group at species level revealed that the relative abundance of Streptococcus mutans, Lactobacillus fermentum, Actinomyces islaelii, Neisseria sica, and Veilonella dispar was much higher in caries group (P < 0.0001). Furthermore, monozygotic twins exhibited a higher degree of similarity than dizygotic twins. Finally, we analyzed the relationship between environmental factors and the oral microbiome, and our results indicat that the frequency of taking sweet food is associated with ECC. We conclude the following. First, the occurrence of Streptococcus mutans, Lactobacillus fermentum, Neisseria sica, and Veilonella dispar is strongly associated with the occurrence of ECC. Second, host genetic factors influence the oral microbiome composition, while environmental and behavioral factors like the frequency of taking sweet foods have an impact on the distribution of caries-related bacteria.
资助项目	National Natural Science Foundation of China[81170954]
WOS关键词	EARLY-CHILDHOOD CARIES ; DENTAL-CARIES ; DIZYGOTIC TWINS ; STREPTOCOCCUS-MUTANS ; PRESCHOOL-CHILDREN ; ENVIRONMENTAL-FACTORS ; BACTERIAL DIVERSITY ; MONOZYGOTIC TWINS ; PERMANENT TEETH ; ACQUISITION
WOS研究方向	Immunology ; Microbiology
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000447377600002
资助机构	National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.qibebt.ac.cn/handle/337004/11751]
专题	中国科学院青岛生物能源与过程研究所
通讯作者	Li, Yuhong; Du, Minquan
作者单位	1.Wuhan Univ, Hubei Most KLOS&KLOBM, Sch & Hosp Stomatol, Wuhan, Hubei, Peoples R China 2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Zheng, Yuqiao,Zhang, Meng,Li, Jin,et al. Comparative Analysis of the Microbial Profiles in Supragingival Plaque Samples Obtained From Twins With Discordant Caries Phenotypes and Their Mothers[J]. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY,2018,8:13.
APA	Zheng, Yuqiao.,Zhang, Meng.,Li, Jin.,Li, Yuhong.,Teng, Fei.,...&Du, Minquan.(2018).Comparative Analysis of the Microbial Profiles in Supragingival Plaque Samples Obtained From Twins With Discordant Caries Phenotypes and Their Mothers.FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY,8,13.
MLA	Zheng, Yuqiao,et al."Comparative Analysis of the Microbial Profiles in Supragingival Plaque Samples Obtained From Twins With Discordant Caries Phenotypes and Their Mothers".FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY 8(2018):13.