Heparin free coating on PLA membranes for enhanced hemocompatibility via iCVD

CORC > 宁波材料技术与工程研究所 > 中国科学院宁波材料技术与工程研究所 > 2018专题

	Heparin free coating on PLA membranes for enhanced hemocompatibility via iCVD
	Wang, Hui; Shi, Xiao; Gao, Ailin; Lin, Haibo; Chen, Yongliang; Ye, Yumin; He, Jidong; Liu, Fu; Deng, Gang
刊名	APPLIED SURFACE SCIENCE
	2018
卷号	433 页码:869-878
关键词	Surface Modification Blood Compatibility Polyethersulfone Membranes Hemodialysis Anticoagulant Biocompatibility Mechanism
英文摘要	In the present work, we report one-step immobilization of nano-heparin coating on PLA membranes via initiated chemical vapor deposition (iCVD) for enhanced hemocompatibility. The nano-coating introduced onto the membrane surface via the crosslinking of P(MAA-EGDA) was confirmed by the FTIR, SEM and weight measurement respectively. The negative carboxyl groups could form the hydration interaction with the protein and platelets and electrostatic interaction with amide groups of thrombin by the mediation of antithrombin, which is similar but different with heparin. The P(MAA-EGDA) coated membranes showed suppressed platelet adhesion and prolonged clotting time (APTTs increased to 59 s, PTs increased to 20.4 s, TTs increased to 17.5 s, and the FIBs declined by 30 mg/dL). Moreover, the complement activation tests demonstrated the formation of C3a and C5a was inhibited. All results demonstrated that the nano-coating of P(MAA-EGDA) via iCVD significantly enhanced the hemocompatibility of PLA membranes, which is also applicable for various membranes. (C) 2017 Elsevier B.V. All rights reserved.
学科主题	Chemistry
语种	英语
公开日期	2018-12-04
内容类型	期刊论文
源URL	[http://ir.nimte.ac.cn/handle/174433/16778]
专题	2018专题
推荐引用方式 GB/T 7714	Wang, Hui,Shi, Xiao,Gao, Ailin,et al. Heparin free coating on PLA membranes for enhanced hemocompatibility via iCVD[J]. APPLIED SURFACE SCIENCE,2018,433:869-878.
APA	Wang, Hui.,Shi, Xiao.,Gao, Ailin.,Lin, Haibo.,Chen, Yongliang.,...&Deng, Gang.(2018).Heparin free coating on PLA membranes for enhanced hemocompatibility via iCVD.APPLIED SURFACE SCIENCE,433,869-878.
MLA	Wang, Hui,et al."Heparin free coating on PLA membranes for enhanced hemocompatibility via iCVD".APPLIED SURFACE SCIENCE 433(2018):869-878.