Tumor-Targeted Accumulation of Ligand-Installed Polymeric Micelles Influenced by Surface PEGylation Crowdedness

CORC > 宁波材料技术与工程研究所 > 中国科学院宁波材料技术与工程研究所 > 2017专题

	Tumor-Targeted Accumulation of Ligand-Installed Polymeric Micelles Influenced by Surface PEGylation Crowdedness
	Chen, Xiyi; Yang, Xi; Chen, Qixian; Yang, Jinjun; Wu, Sudong; Liu, Jun; Li, Zhen; Liu, Deqiang; Qiu, Yongming
刊名	ACS APPLIED MATERIALS & INTERFACES
	2017
卷号	9 期号:50 页码:44045-44052
关键词	Polyplex Micelle Cancer-therapy Drug-delivery Nanoparticle Therapeutics Future Size
英文摘要	With respect to the intriguing biocompatibility and the stealthy functions of poly(ethylene glycol),(PEGE), PEGylated nanopatticulates have- been intensively engineered for utilities as diug delivery vehicles.7o advocate the targeted druorinsportation, targeting ligands were strategically installed onto the surfaCe of PEGylated "nanoparticulates. The previous in vitro investigations revealed that the ligancl-specified cell endocytosis of nanopartictilates was pronounced for the nanoparticulates with adequately high PEG crowdedness. The present study aims to explore insight into the impact of PEGylation degree on in vivo tumor-targeted accumulation activities of cRGD-installed nanoparticulates. The subsequent investigations verified the importance of the PEGylation crowdedness in pursuit of prolonged retention in the blood circulation post intravenous administration. Unprecedettedly, the PEGylation crowdedness was also identified as a crucial important parameter to pursue the tumor-targeted accumulation. A plausible reason is the elevated PEGylation crowdedness eliciting the restricted involvement iri nonspecific protein adsorption of nanoparticulates in the biological milieu and consequently pronouncing the ligand-receptor-mediated binding for the nanoparticulates. Notewoithy was the distinctive performance Of the class of the proposed systems once utilized for transportation of the mRNA payload to the tumors. The protein expression in the targeted tumors appeared to follow a clear PEGylation crowdedness dependence manner, where merely 2-fold PEGylation crowdedness led to remarkably 10-fold augmentation in protein expression in tumors. Hence, the results provided important information and implications for design of active-targeting PEGylated nanomaterials to fulfill the targeting strategies in systemic applications.
学科主题	Chemistry ; Materials Science ; Metallurgy & Metallurgical Engineering
语种	英语
公开日期	2018-12-04
内容类型	期刊论文
源URL	[http://ir.nimte.ac.cn/handle/174433/17486]
专题	2017专题
推荐引用方式 GB/T 7714	Chen, Xiyi,Yang, Xi,Chen, Qixian,et al. Tumor-Targeted Accumulation of Ligand-Installed Polymeric Micelles Influenced by Surface PEGylation Crowdedness[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(50):44045-44052.
APA	Chen, Xiyi.,Yang, Xi.,Chen, Qixian.,Yang, Jinjun.,Wu, Sudong.,...&Qiu, Yongming.(2017).Tumor-Targeted Accumulation of Ligand-Installed Polymeric Micelles Influenced by Surface PEGylation Crowdedness.ACS APPLIED MATERIALS & INTERFACES,9(50),44045-44052.
MLA	Chen, Xiyi,et al."Tumor-Targeted Accumulation of Ligand-Installed Polymeric Micelles Influenced by Surface PEGylation Crowdedness".ACS APPLIED MATERIALS & INTERFACES 9.50(2017):44045-44052.