In order to investigate the chemical compatibility between tritium breeder Li2TiO3 pebbles and tritium breeder blanket material oxide dispersion strengthened (ODS) steel, the contact interface between Li2TiO3 pebbles and ODS steel heated in argon atmosphere at 500, 600 and 700 degrees C for 300 h was studied. It was found that the ions of pebbles could diffuse and corrode with the cladding material after a long-time reaction at high temperature. The corrosion area formed on the surface of Li2TiO3 pebbles was small. With the increase of temperature, a zone with enriched iron was found on the surface of the pebble. This part of the surface was the direct contact surface between the pebble and the steel. At the same time, the relative density of the pebbles increased and the crush load was decreased to 30 N. In addition, a slight corrosion phenomenon was found on the surface of ODS steel. It has been proved that the main components of the corrosion products were the complex oxide containing Fe and Cr and the complex oxide containing Li and Fe.