Bridging Systemic Immunity with Gastrointestinal Immune Responses via Oil-in-Polymer Capsules | |
Xia, Yufei1,2; Wu, Jie1,3,4; Du, Yiqun5; Miao, Chunyu1; Su, Zhiguo1,3,4,6; Ma, Guanghui1,3,4,6 | |
刊名 | ADVANCED MATERIALS |
2018-08-02 | |
卷号 | 30期号:31页码:8 |
关键词 | Gastrointestinal Infections Gut Tropism Mucosal Immunity Oil-in-polymer Capsules Retinoic Acid |
ISSN号 | 0935-9648 |
DOI | 10.1002/adma.201801067 |
英文摘要 | As peripheral lymphocytes are typically excluded from the gastrointestinal lymph tissues, current parenteral vaccinations fail to simultaneously induce systemic and mucosal responses. To break the natural barrier, "immunoticket" capsules are developed and heralded, which are designed with positive charged shells and oily core to spatiotemporally deliver antigens and all-trans retinoic acid (RA). After intramuscular vaccinations, these capsules function as an immunoticket to cultivate peripheral dendritic cells (DCs) with gut-homing receptors (CCR9). By hitchhiking on the concentration gradient of the CC-motif chemokine ligand 25 (CCL25), the primed DCs would home to the gut associated lymphoid tissues (GALTs) and induce antigen-specific IgA secretion and T cell engagements. Compared with the currently employed RA-involving formulations, the immunoticket capsules stimulate enhanced RA-mediated guttropism by mounting the inflammatory innate immunity. Through controlling the RA payload, the potential regulatory T cell engagement is circumvented. In ovalbumin (OVA) and EV71 vaccinations, the immunoticket capsules induce potent serum IgG titer and antigen-specific cytotoxic T cells in the peripheral lymph tissues, as well as robust IgA secretion and T cell engagements on gastrointestinal sites. The data suggest the potential of the immunotickets to serve as a facile, effective, and safe strategy to provide comprehensive immune responses against gastrointestinal infections and diseases |
资助项目 | National Science and Technology Major Project[2014ZX09102045] ; National Natural Science Foundation of China (NSFC) project[21776287] ; National Natural Science Foundation of China (NSFC) project[21576268] |
WOS关键词 | Regulatory T-cells ; Trans-retinoic Acid ; Dendritic Cells ; Drug-delivery ; Innate Immune ; Release ; Cancer ; Gut ; Induce ; Immunotherapy |
WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
语种 | 英语 |
出版者 | WILEY-V C H VERLAG GMBH |
WOS记录号 | WOS:000443807400028 |
资助机构 | National Science and Technology Major Project ; National Natural Science Foundation of China (NSFC) project |
内容类型 | 期刊论文 |
源URL | [http://ir.ipe.ac.cn/handle/122111/25913] |
专题 | 中国科学院过程工程研究所 |
通讯作者 | Su, Zhiguo; Ma, Guanghui |
作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, PLA Key Lab Biopharmaceut Prod, Beijing 100190, Peoples R China 4.Chinese Acad Sci, Formulat Engn Inst Proc Engn, Beijing 100190, Peoples R China 5.Jiangnan Univ, Minist Educ, Key Lab Carbohydrate Chem & Biotechnol, Sch Biotechnol, Wuxi 214122, Peoples R China 6.Jiangsu Natl Synerget Innovat Ctr Adv Mat, Nanjing 211816, Jiangsu, Peoples R China |
推荐引用方式 GB/T 7714 | Xia, Yufei,Wu, Jie,Du, Yiqun,et al. Bridging Systemic Immunity with Gastrointestinal Immune Responses via Oil-in-Polymer Capsules[J]. ADVANCED MATERIALS,2018,30(31):8. |
APA | Xia, Yufei,Wu, Jie,Du, Yiqun,Miao, Chunyu,Su, Zhiguo,&Ma, Guanghui.(2018).Bridging Systemic Immunity with Gastrointestinal Immune Responses via Oil-in-Polymer Capsules.ADVANCED MATERIALS,30(31),8. |
MLA | Xia, Yufei,et al."Bridging Systemic Immunity with Gastrointestinal Immune Responses via Oil-in-Polymer Capsules".ADVANCED MATERIALS 30.31(2018):8. |
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