Charge-Induced Secondary Structure Transformation of Amyloid-Derived Dipeptide Assemblies from beta-Sheet to alpha-Helix | |
Xing, Ruirui1; Yuan, Chengqian1,2; Li, Shukun1,4; Song, Jingwen1; Li, Junbai3; Yan, Xuehai1,2,4 | |
刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION |
2018-02-05 | |
卷号 | 57期号:6页码:1537-1542 |
关键词 | Gels Nanofibers Peptides Phase Transitions Self-assembly |
ISSN号 | 1433-7851 |
DOI | 10.1002/anie.201710642 |
文献子类 | Article |
英文摘要 | Secondary structures such as alpha-helix and beta-sheet are the major structural motifs within the three-dimensional geometry of proteins. Therefore, structure transitions from beta-sheet to alpha-helix not only can serve as an effective strategy for the therapy of neurological diseases through the inhibition of -sheet aggregation but also extend the application of alpha-helix fibrils in biomedicine. Herein, we present a charge-induced secondary structure transition of amyloid-derived dipeptide assemblies from beta-sheet to alpha-helix. We unravel that the electrostatic (charge) repulsion between the C-terminal charges of the dipeptide molecules are responsible for the conversion of the secondary structure. This finding provides a new perspective to understanding the secondary structure formation and transformation in the supramolecular organization and life activity. |
WOS关键词 | Supramolecular Hydrogels ; Infrared-spectroscopy ; Peptide Amphiphiles ; Protein-structure ; Self-assembles ; Architecture ; Temperature ; Solvent ; Switch |
WOS研究方向 | Chemistry |
语种 | 英语 |
WOS记录号 | WOS:000423494500017 |
资助机构 | National Natural Science Foundation of China(21522307 ; Talent Fund of the Recruitment Program of Global Youth Experts ; Key Research Program of Frontier Sciences of Chinese Academy of Sciences (CAS)(QYZDB-SSW-JSC034) ; CAS President's International Fellowship Initiative(2017DE0004 ; 21473208 ; 2017VEA0023) ; 91434103) |
内容类型 | 期刊论文 |
源URL | [http://ir.ipe.ac.cn/handle/122111/23986] |
专题 | 过程工程研究所_生化工程国家重点实验室 |
作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, Ctr Mesosci, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Key Lab Colloid & Interface Sci, Beijing 100190, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
推荐引用方式 GB/T 7714 | Xing, Ruirui,Yuan, Chengqian,Li, Shukun,et al. Charge-Induced Secondary Structure Transformation of Amyloid-Derived Dipeptide Assemblies from beta-Sheet to alpha-Helix[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2018,57(6):1537-1542. |
APA | Xing, Ruirui,Yuan, Chengqian,Li, Shukun,Song, Jingwen,Li, Junbai,&Yan, Xuehai.(2018).Charge-Induced Secondary Structure Transformation of Amyloid-Derived Dipeptide Assemblies from beta-Sheet to alpha-Helix.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,57(6),1537-1542. |
MLA | Xing, Ruirui,et al."Charge-Induced Secondary Structure Transformation of Amyloid-Derived Dipeptide Assemblies from beta-Sheet to alpha-Helix".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57.6(2018):1537-1542. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论