In this paper, a model of predicting the reaction in CFB was developed by coupling some developed sub-grid models into the Euler-Euler two-phase flow model (TFM) with the relatively coarse mesh. In this model, the local heterogeneous flow structural parameters were obtained by solving the momentum and mass conservation equations and using some widely accepted semi-empirical equations, for example, the well-known Ergun and Richardson-Zaki equation. The heterogeneous fluid flow was resolved by coupling the momentum transfer coefficient based on the local heterogeneous structural parameters into the TFM model. The gas-solid mass transfer coefficient in terms of the local heterogeneous fluid flow was obtained in the assumed process, which was completely dominated by the gas-solid mass transfer. And then, the reaction was predicted by solving the balance equation between the mass transfer and chemical reaction. This method improves the general applicability of developed model and reduces the calculating process, and which has been verified by the ozone decomposition reaction in CFB from the literature. (C) 2017 Elsevier B.V. All rights reserved.