40,000-Year-Old Individual from Asia Provides Insight into Early Population Structure in Eurasia

doi:10.1016/j.cub.2017.09.030

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	40,000-Year-Old Individual from Asia Provides Insight into Early Population Structure in Eurasia
	Yang, Melinda A.1,2,3; Gao, Xing1,2,3 ; Theunert, Christoph 4,5; Tong, Haowen1 ; Aximu-Petri, Ayinuer 2,3,5; Nickel, Birgit 5; Slatkin, Montgomery 4; Meyer, Matthias 2,3,5; Paeaebo, Svante 2,3,5; Kelso, Janet 2,3,5
刊名	CURRENT BIOLOGY
	2017-10-23
卷号	27 期号:20 页码:3202-+
DOI	10.1016/j.cub.2017.09.030
文献子类	Article
英文摘要	By at least 45,000 years before present, anatomically modern humans had spread across Eurasia [1-3], but it is not well known how diverse these early populations were and whether they contributed substantially to later people or represent early modern human expansions into Eurasia that left no surviving descendants today. Analyses of genome-wide data from several ancient individuals from Western Eurasia and Siberia have shown that some of these individuals have relationships to present-day Europeans [4, 5] while others did not contribute to present-day Eurasian populations [3, 6]. As contributions from Upper Paleolithic populations in Eastern Eurasia to present-day humans and their relationship to other early Eurasians is not clear, we generated genome-wide data from a 40,000-year-old individual from Tianyuan Cave, China, [1, 7] to study his relationship to ancient and present-day humans. We find that he is more related to present-day and ancient Asians than he is to Europeans, but he shares more alleles with a 35,000-year-old European individual than he shares with other ancient Europeans, indicating that the separation between earlyEuropeans and early Asians was not a single population split. We also find that the Tianyuan individual shares more alleles with some Native American groups in South America than with Native Americans elsewhere, providing further support for population substructure in Asia [8] and suggesting that this persisted from 40,000 years ago until the colonization of the Americas. Our study of the Tianyuan individual highlights the complex migration and subdivision of early human populations in Eurasia.
WOS关键词	GENOME SEQUENCE ; MITOCHONDRIAL GENOMES ; HUMAN-EVOLUTION ; TIANYUAN CAVE ; MUTATION-RATE ; HISTORY ; NEANDERTHAL ; EAST ; EUROPEANS ; ADMIXTURE
WOS研究方向	Biochemistry & Molecular Biology ; Cell Biology
语种	英语
WOS记录号	WOS:000413441700034
资助机构	National Science Foundation of China (NSFC)(91731303) ; Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences(XDB13000000) ; National Key R&D Program of China(2016YFE0203700) ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences(QYZDB-SS W-DQC003 ; NSFC(41672021 ; Howard Hughes Medical Institute(55008731) ; Max Planck Society ; Krekeler Foundation ; European Research Council(694707) ; United States NIH grant(R01-GM40282) ; XDPB05) ; 41630102 ; 41672024 ; 41572003)
内容类型	期刊论文
源URL	[http://124.16.247.212/handle/311034/7950]
专题	古脊椎动物与古人类研究所_图书馆1
作者单位	1.Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Key Lab Vertebrate Evolut & Human Origins, Beijing 100044, Peoples R China 2.Chinese Acad Sci, Lab Mol Paleontol, Max Planck Inst Evolutionary Anthropol, Beijing 100044, Peoples R China 3.Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Beijing 100044, Peoples R China 4.Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94720 USA 5.Max Planck Inst Evolutionary Anthropol, Dept Evolutionary Genet, D-04103 Leipzig, Germany
推荐引用方式 GB/T 7714	Yang, Melinda A.,Gao, Xing,Theunert, Christoph,et al. 40,000-Year-Old Individual from Asia Provides Insight into Early Population Structure in Eurasia[J]. CURRENT BIOLOGY,2017,27(20):3202-+.
APA	Yang, Melinda A..,Gao, Xing.,Theunert, Christoph.,Tong, Haowen.,Aximu-Petri, Ayinuer.,...&Fu, Qiaomei.(2017).40,000-Year-Old Individual from Asia Provides Insight into Early Population Structure in Eurasia.CURRENT BIOLOGY,27(20),3202-+.
MLA	Yang, Melinda A.,et al."40,000-Year-Old Individual from Asia Provides Insight into Early Population Structure in Eurasia".CURRENT BIOLOGY 27.20(2017):3202-+.