A high-coverage Neandertal genome from Vindija Cave in Croatia

doi:10.1126/science.aao1887

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	A high-coverage Neandertal genome from Vindija Cave in Croatia
	Pruefer, Kay 1; de Filippo, Cesare 1; Grote, Steffi 1; Mafessoni, Fabrizio 1; Korlevic, Petra 1; Hajdinjak, Mateja 1; Vernot, Benjamin 1; Skov, Laurits 2; Hsieh, Pinghsun 3; Peyregne, Stephane 1
刊名	SCIENCE
	2017-11-03
卷号	358 期号:6363 页码:655-658
DOI	10.1126/science.aao1887
文献子类	Article
英文摘要	To date, the only Neandertal genome that has been sequenced to high quality is from an individual found in Southern Siberia. We sequenced the genome of a female Neandertal from similar to 50,000 years ago from Vindija Cave, Croatia, to similar to 30-fold genomic coverage. She carried 1.6 differences per 10,000 base pairs between the two copies of her genome, fewer than present-day humans, suggesting that Neandertal populations were of small size. Our analyses indicate that she was more closely related to the Neandertals that mixed with the ancestors of present-day humans living outside of sub-Saharan Africa than the previously sequenced Neandertal from Siberia, allowing 10 to 20% more Neandertal DNA to be identified in present-day humans, including variants involved in low-density lipoprotein cholesterol concentrations, schizophrenia, and other diseases.
WOS关键词	MODERN HUMANS ; ADMIXTURE ; SEQUENCE ; ANCIENT ; DNA ; INTROGRESSION ; POPULATIONS ; ANCESTRY
WOS研究方向	Science & Technology - Other Topics
语种	英语
WOS记录号	WOS:000414240500039
资助机构	National Key R&D Program of China(2016YFE0203700) ; Chinese Academy of Sciences(XDB13000000 ; National Natural Science Foundation of China(91731303 ; Howard Hughes Medical Institute(55008731) ; U.S. National Science Foundation(BCS-1032255) ; investigator of the Howard Hughes Medical Institute ; U.S. National Institutes of Health(NIH R01HGO02385) ; European Research Council(694707) ; Max Planck Foundation(31-12LMP Paabo) ; QYZDB-SS W-DQCO03 ; 41672021 ; XDPB05) ; 41630102)
内容类型	期刊论文
源URL	[http://124.16.247.212/handle/311034/7917]
专题	古脊椎动物与古人类研究所_图书馆1
作者单位	1.Max Planck Inst Evolutionary Anthropol, D-04103 Leipzig, Germany 2.Aarhus Univ, Bioinformat Res Ctr, DK-8000 Aarhus C, Denmark 3.Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA 98195 USA 4.Chinese Acad Sci, Key Lab Vertebrate Evolut & Human Origins, Inst Vertebrate Paleontol & Paleoanthropol, Beijing 100044, Peoples R China 5.Broad Inst MIT & Harvard, Cambridge, MA 02142 USA 6.Croatian Acad Sci & Arts, Anthropol Ctr, Zagreb 10000, Croatia 7.ANO Lab Prehist 14 Linia 3 11, St Petersburg 199034, Russia 8.Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94720 USA 9.Harvard Med Sch, Dept Genet, Boston, MA 02115 USA 10.Harvard Med Sch, Howard Hughes Med Inst, Boston, MA 02115 USA
推荐引用方式 GB/T 7714	Pruefer, Kay,de Filippo, Cesare,Grote, Steffi,et al. A high-coverage Neandertal genome from Vindija Cave in Croatia[J]. SCIENCE,2017,358(6363):655-658.
APA	Pruefer, Kay.,de Filippo, Cesare.,Grote, Steffi.,Mafessoni, Fabrizio.,Korlevic, Petra.,...&Paabo, Svante.(2017).A high-coverage Neandertal genome from Vindija Cave in Croatia.SCIENCE,358(6363),655-658.
MLA	Pruefer, Kay,et al."A high-coverage Neandertal genome from Vindija Cave in Croatia".SCIENCE 358.6363(2017):655-658.