Cytotoxic Polyketides with an Oxygen-Bridged Cyclooctadiene Core Skeleton from the Mangrove Endophytic Fungus Phomosis sp. A818

doi:doi:10.3390/molecules22091547

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	Cytotoxic Polyketides with an Oxygen-Bridged Cyclooctadiene Core Skeleton from the Mangrove Endophytic Fungus Phomosis sp. A818
	Wei Zhang; Baobing Zhao; Liangcheng Du; Yuemao Shen
刊名	Molecules
	2017
卷号	22 页码:1547-1555
DOI	doi:10.3390/molecules22091547
文献子类	Article
英文摘要	Plant endophytic microorganisms represent a largely untapped resource for new bioactive natural products. Eight polyketide natural products were isolated from a mangrove endophytic fungus Phomosis sp. A818. The structural elucidation of these compounds revealed that they share a distinct feature in their chemical structures, an oxygen-bridged cyclooctadiene core skeleton. The study on their structure–activity relationship showed that the α,β -unsaturated -lactone moiety, as exempliﬁed in compounds 1 and 2, was critical to the cytotoxic activity of these compounds. In addition, compound 4 might be a potential agonist of AMPK (50-adenosine monophosphate-activated protein kinase).
WOS关键词	polyketide ; mycoepoxydiene ; cyclooctadiene ; endophtic fungus ; cytotoxicity
WOS研究方向	Microbiology
语种	英语
资助机构	NSFC (31570030) ; Youth Innovation Promotion Association CAS to W.Z. (2015166) ; Nebraska Research Initiatives ; China Postdoctoral Science Found (2015M580606 and 2016M580606).
内容类型	期刊论文
源URL	[http://ir.qibebt.ac.cn/handle/337004/9858]
专题	青岛生物能源与过程研究所_酶工程团队
推荐引用方式 GB/T 7714	Wei Zhang,Baobing Zhao,Liangcheng Du,et al. Cytotoxic Polyketides with an Oxygen-Bridged Cyclooctadiene Core Skeleton from the Mangrove Endophytic Fungus Phomosis sp. A818[J]. Molecules,2017,22:1547-1555.
APA	Wei Zhang,Baobing Zhao,Liangcheng Du,&Yuemao Shen.(2017).Cytotoxic Polyketides with an Oxygen-Bridged Cyclooctadiene Core Skeleton from the Mangrove Endophytic Fungus Phomosis sp. A818.Molecules,22,1547-1555.
MLA	Wei Zhang,et al."Cytotoxic Polyketides with an Oxygen-Bridged Cyclooctadiene Core Skeleton from the Mangrove Endophytic Fungus Phomosis sp. A818".Molecules 22(2017):1547-1555.