Tailoring cyanobacterial cell factory for improved industrial properties

doi:10.1016/j.biotechadv.2018.01.005

CORC > 青岛生物能源与过程研究所 > 中国科学院青岛生物能源与过程研究所 > 微生物代谢工程团队

	Tailoring cyanobacterial cell factory for improved industrial properties
	Luan, Guodong 1,2; Lu, Xuefeng 1,2,3
刊名	BIOTECHNOLOGY ADVANCES
	2018-03-01
卷号	36 期号:2 页码:430-442
关键词	Cyanobacteria Photosynthetic Biomanufacturing Metabolic Engineering Scaled Cultivation Day-night Cycles Cellular Robustness Biocontaminants Resistance Biomass Harvest Product Recovery
ISSN号	0734-9750
DOI	10.1016/j.biotechadv.2018.01.005
文献子类	Review
英文摘要	Photosynthetic biomanufacturing provides a promising solution for sustainable production of biofuels and biochemicals. Cyanobacteria are among the most promising microbial platforms for the construction of photosynthetic cell factories. Metabolic engineering of cyanobacteria has enabled effective photosynthetic synthesis of diverse natural or non-natural metabolites, while commercialization of photosynthetic biomanufacturing is usually restricted by process and economic feasibilities. In actual outdoor conditions, active cell growth and product synthesis is restricted to narrow light exposure windows of the day-night cycles and is threatened by diverse physical, chemical, and biological environmental stresses. For biomass harvesting and bioproduct recovery, energy and cost consuming processing and equipment is required, which further decreases the economic and environmental competitiveness of the entire process. To facilitate scaled photosynthetic biomanufacturing, lots of efforts have been made to engineer cyanobacterial cell properties required by robust & continual cultivation and convenient & efficient recovery. In this review, we specifically summarized recently reported engineering strategies on optimizing industrial properties of cyanobacterial cells. Through systematically re-editing the metabolism, morphology, mutualism interaction of cyanobacterial chassis cells, the adaptabilities and compatibilities of the cyanobacterial cell factories to the industrial process could be significantly improved. Cell growth and product synthesis of the tailored cyanobacterial cells could be expanded and maintained at night and in stressful environments, while convenient biomass harvesting could also be expected. For developing more feasible cyanobacterial photosynthetic biomanufacturing in large scale, we here propose the importance of tailoring industrial properties of cyanobacteria and outline the directions that should be exploited in the future.
WOS关键词	SP PCC 6803 ; OBLIGATE PHOTOAUTOTROPHIC CYANOBACTERIUM ; APHANOTHECE-HALOPHYTICA CONTAINS ; FRESH-WATER CYANOBACTERIUM ; SYNECHOCOCCUS-ELONGATUS ; CARBON-DIOXIDE ; ESCHERICHIA-COLI ; PHOTOSYNTHETIC PRODUCTION ; STRESS TOLERANCE ; CHEMICAL PRODUCTION
WOS研究方向	Biotechnology & Applied Microbiology
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000428823300007
资助机构	National Science Foundation(31525002 ; Shandong Natural Science Foundation(JQ201306 ; Shandong Province (Taishan Scholarship) ; City of Qingdao (Qingdao Innovative Leading Talent) ; 31600034 ; ZR2017ZB0211) ; 3171101192 ; 31770092)
内容类型	期刊论文
源URL	[http://ir.qibebt.ac.cn/handle/337004/10751]
专题	青岛生物能源与过程研究所_微生物代谢工程团队
通讯作者	Lu, Xuefeng
作者单位	1.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Key Lab Biofuels, 189 Songling Rd, Qingdao 266101, Peoples R China 2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Shandong Prov Key Lab Synthet Biol, 189 Songling Rd, Qingdao 266101, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
推荐引用方式 GB/T 7714	Luan, Guodong,Lu, Xuefeng. Tailoring cyanobacterial cell factory for improved industrial properties[J]. BIOTECHNOLOGY ADVANCES,2018,36(2):430-442.
APA	Luan, Guodong,&Lu, Xuefeng.(2018).Tailoring cyanobacterial cell factory for improved industrial properties.BIOTECHNOLOGY ADVANCES,36(2),430-442.
MLA	Luan, Guodong,et al."Tailoring cyanobacterial cell factory for improved industrial properties".BIOTECHNOLOGY ADVANCES 36.2(2018):430-442.