A physically crosslinked polydopamine/nanocellulose hydrogel as potential versatile vehicles for drug delivery and wound healing

doi:10.1016/j.carbpol.2018.01.093

CORC > 青岛生物能源与过程研究所 > 中国科学院青岛生物能源与过程研究所 > 绿色化学催化团队

	A physically crosslinked polydopamine/nanocellulose hydrogel as potential versatile vehicles for drug delivery and wound healing
	Liu, Yingying 1,2; Sui, Yulong 3; Liu, Chao 2; Liu, Changqing 2; Wu, Meiyan 2; Li, Bin 2; Li, Youming 1
刊名	CARBOHYDRATE POLYMERS
	2018-05-15
卷号	188 页码:27-36
关键词	Nanocellulose Cellulose Nanofibrils Polydopamine Hydrogel Drug Delivery Wound Healing
ISSN号	0144-8617
DOI	10.1016/j.carbpol.2018.01.093
文献子类	Article
英文摘要	In this study, we reported a pH/near-infrared (NIR)-responsive hydrogel for on-demand drug delivery and wound healing. Cellulose nanofibrils (TOCNFs) were produced by 2, 2, 6, 6-tetramethylpiperidine-1-oxyl (TEMPO)-mediated oxidation method. Polydopamine (PDA) was introduced into TOCNFs network to fabricate a PDA/TOCNFs hydrogel through ion-crosslinking with calcium ion as a crosslinker. Then, tetracycline hydrochloride (TH) which loaded on PDA could be released from the prepared hydrogels in an on-demand fashion under NIR exposure or at lower pH conditions. In addition, the in vivo skin defect experiments illustrated that the resultant composite hydrogel had a synergistic effect on promoting wound healing. Therefore, owing to the unique pH/NIR responsiveness, long time period drug releasing property, antibacterial and mechanical properties, together with their biodegradability and biocompatibility, the prepared PDA/TOCNFs hydrogel is highly promising as a new drug delivery vehicle, offering simple and safe alternatives to the conventional systems based on the petroleum-based polymers.
WOS关键词	TETRACYCLINE HYDROCHLORIDE ; RELEASE DYNAMICS ; FORMIC-ACID ; CELLULOSE ; OXIDATION ; SURFACES ; THERAPY ; SYSTEMS
WOS研究方向	Chemistry ; Polymer Science
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000426963900004
资助机构	National Natural Science Foundation of China(31470609 ; National Key Research and Development Program of China(2017YFB0307900) ; Primary Research and Development Plan of Shandong Province(2016CYJS07A02) ; 31700509 ; 21476091)
内容类型	期刊论文
源URL	[http://ir.qibebt.ac.cn/handle/337004/10683]
专题	青岛生物能源与过程研究所_绿色化学催化团队
通讯作者	Li, Bin; Li, Youming
作者单位	1.South China Univ Technol, State Key Lab Pulp & Paper Engn, Guangzhou 510640, Guangdong, Peoples R China 2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, CAS Key Lab Biobased Mat, Qingdao 266101, Peoples R China 3.Qingdao Univ, Cardiovasc Surg Dept, Affiliated Hosp, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Liu, Yingying,Sui, Yulong,Liu, Chao,et al. A physically crosslinked polydopamine/nanocellulose hydrogel as potential versatile vehicles for drug delivery and wound healing[J]. CARBOHYDRATE POLYMERS,2018,188:27-36.
APA	Liu, Yingying.,Sui, Yulong.,Liu, Chao.,Liu, Changqing.,Wu, Meiyan.,...&Li, Youming.(2018).A physically crosslinked polydopamine/nanocellulose hydrogel as potential versatile vehicles for drug delivery and wound healing.CARBOHYDRATE POLYMERS,188,27-36.
MLA	Liu, Yingying,et al."A physically crosslinked polydopamine/nanocellulose hydrogel as potential versatile vehicles for drug delivery and wound healing".CARBOHYDRATE POLYMERS 188(2018):27-36.