Biosynthesis of nervonic acid and perspectives for its production by microalgae and other microorganisms

doi:10.1007/s00253-018-8859-y

	Biosynthesis of nervonic acid and perspectives for its production by microalgae and other microorganisms
	Fan, Yong; Meng, Hui-Min; Hu, Guang-Rong; Li, Fu-
刊名	APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
	2018-04-01
卷号	102 期号:7 页码:3027-3035
关键词	Very Long-chain Monounsaturated Fatty Acids Synthetic Biology Metabolic Engineering Cellular Engineering 3-ketoacyl-coa Synthesis
ISSN号	0175-7598
DOI	10.1007/s00253-018-8859-y
文献子类	Review
英文摘要	Nervonic acid (NA) is a major very long-chain monounsaturated fatty acid found in the white matter of mammalian brains, which plays a critical role in the treatment of psychotic disorders and neurological development. In the nature, NA has been synthesized by a handful plants, fungi, and microalgae. Although the metabolism of fatty acid has been studied for decades, the biosynthesis of NA has yet to be illustrated. Generally, the biosynthesis of NA is considered starting from oleic acid through fatty acid elongation, in which malonyl-CoA and long-chain acyl-CoA are firstly condensed by a rate-limiting enzyme 3-ketoacyl-CoA synthase (KCS). Heterologous expression of kcs gene from high NA producing species in plants and yeast has led to synthesis of NA. Nevertheless, it has also been reported that desaturases in a few plants can catalyze very long-chain saturated fatty acid into NA. This review highlights recent advances in the biosynthesis, the sources, and the biotechnological aspects of NA.
WOS关键词	DNA-POLYMERASE-BETA ; RATE-LIMITING STEP ; CHAIN FATTY-ACIDS ; SACCHAROMYCES-CEREVISIAE ; ARABIDOPSIS-THALIANA ; YARROWIA-LIPOLYTICA ; GENE FAMILY ; 3-KETOACYL-COA SYNTHASES ; SUBSTRATE-SPECIFICITY ; MORTIERELLA-ALPINA
WOS研究方向	Biotechnology & Applied Microbiology
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000427579600008
资助机构	National Natural Science Foundation of China(31602154) ; Shandong Province Natural Science Major Program(ZR2017ZB0209) ; Shandong Province Natural Science Funds for Young Scholar(JQ201507 ; ZR2017BC108)
内容类型	期刊论文
源URL	[http://ir.qibebt.ac.cn/handle/337004/10673]
专题	中国科学院青岛生物能源与过程研究所
通讯作者	Li, Fu-
作者单位	Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao Engn Lab Single Cell Oil, Shandong Prov Key Lab Synthet Biol,Key Lab Biofue, 189 Songling Rd, Qingdao 266101, Peoples R China
推荐引用方式 GB/T 7714	Fan, Yong,Meng, Hui-Min,Hu, Guang-Rong,et al. Biosynthesis of nervonic acid and perspectives for its production by microalgae and other microorganisms[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2018,102(7):3027-3035.
APA	Fan, Yong,Meng, Hui-Min,Hu, Guang-Rong,&Li, Fu-.(2018).Biosynthesis of nervonic acid and perspectives for its production by microalgae and other microorganisms.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,102(7),3027-3035.
MLA	Fan, Yong,et al."Biosynthesis of nervonic acid and perspectives for its production by microalgae and other microorganisms".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 102.7(2018):3027-3035.