A review on chiral separation by counter-current chromatography: Development, applications and future outlook

doi:10.1016/j.chroma.2017.10.073

	A review on chiral separation by counter-current chromatography: Development, applications and future outlook
	Huang, Xin-Yi 1,2; Pei, Dong 1,2,3; Liu, Jian-Fei 1,2; Di, Duo-Long 1,2,3
刊名	JOURNAL OF CHROMATOGRAPHY A
	2018-01-05
卷号	1531 页码:1-12
关键词	Chiral Separation High-speed Counter Current Chromatography Centrifugal Partition Chromatography
ISSN号	0021-9673
DOI	10.1016/j.chroma.2017.10.073
文献子类	Review
英文摘要	Chiral separation has been a remarkably active area of research over the past long time and it still stays that way. Over the last few decades, counter-current chromatography (CCC) was successfully applied to the field of chiral separation. It provides an attractive approach to obtain pure enantiomer, particularly in preparative application because of its unique advantages of high load capacity, low solvent consumption and easy scale-up. The last several years great strides have been made in chiral separation by CCC, ranging from novel elution modes such as recycling elution mode and multiple dual mode elution to more specialized approaches such as pH-zone-refining and biphasic chiral recognition technologies. These developments have greatly improved the resolution of enantiomers and promoted the application of CCC in the field of chiral separation. Although not as popular as its application to the field of separation of natural product, the development of chiral separation by CCC should not be underrated. In this review article, we refer to the development, applications and future outlook of chiral separation by CCC, with emphasis on topics of its history, mechanism, advantages, limitations, current development and challenges. Meanwhile, its orientation of continued evolution and future outlook also have been discussed. While some scientific and technological problems have not yet been solved thoroughly, chiral separation by CCC has demonstrated potential advantages and prospects in this field and has good chance at preparative enantioseparation. (C) 2017 Published by Elsevier B.V.
WOS关键词	CENTRIFUGAL PARTITION CHROMATOGRAPHY ; PERFORMANCE LIQUID-CHROMATOGRAPHY ; HYDROXYPROPYL-BETA-CYCLODEXTRIN ; IONIC LIQUIDS ; PREPARATIVE ENANTIOSEPARATION ; CAPILLARY-ELECTROPHORESIS ; ENANTIOMERIC SEPARATION ; EXPERIMENTAL-VERIFICATION ; ANALYTICAL-CHEMISTRY ; L-(+)-TARTARIC ACID
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000423651300001
资助机构	National Natural Sciences Foundation of China (NSFC)(21505144 ; Natural Science Foundation of Gansu Province(1506RJZA283) ; Youth Innovation Promotion Association CAS(2016369) ; 21605149)
内容类型	期刊论文
源URL	[http://ir.qibebt.ac.cn/handle/337004/10587]
专题	中国科学院青岛生物能源与过程研究所
通讯作者	Huang, Xin-Yi; Di, Duo-Long
作者单位	1.Chinese Acad Sci, Lanzhou Inst Chem Phys, CAS Key Lab Chem Northwestern Plant Resources, Lanzhou, Gansu, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou, Gansu, Peoples R China 3.Chinese Acad Sci, Lanzhou Inst Chem Phys, Ctr Resource Chem & New Mat, Qingdao, Peoples R China
推荐引用方式 GB/T 7714	Huang, Xin-Yi,Pei, Dong,Liu, Jian-Fei,et al. A review on chiral separation by counter-current chromatography: Development, applications and future outlook[J]. JOURNAL OF CHROMATOGRAPHY A,2018,1531:1-12.
APA	Huang, Xin-Yi,Pei, Dong,Liu, Jian-Fei,&Di, Duo-Long.(2018).A review on chiral separation by counter-current chromatography: Development, applications and future outlook.JOURNAL OF CHROMATOGRAPHY A,1531,1-12.
MLA	Huang, Xin-Yi,et al."A review on chiral separation by counter-current chromatography: Development, applications and future outlook".JOURNAL OF CHROMATOGRAPHY A 1531(2018):1-12.