The Cucurbit[7]Uril-Based Supramolecular Chemistry for Reversible B/Z-DNA Transition

doi:10.1002/advs.201800231

	The Cucurbit[7]Uril-Based Supramolecular Chemistry for Reversible B/Z-DNA Transition
	Wang, Shao-Ru 2; Wang, Jia-Qi 2; Xu, Guo-Hua 1; Wei, Lai 2; Fu, Bo-Shi 2; Wu, Ling-Yu 2; Song, Yan-Yan 2; Yang, Xi-Ran 3; Li, Conggang 1; Liu, Si-Min 3
刊名	ADVANCED SCIENCE
	2018-07-01
卷号	5 期号:7
关键词	Cucurbit[7]Uril Reversible B/z-dna Transitions Spermine Supramolecular Chemistry
ISSN号	2198-3844
DOI	10.1002/advs.201800231
文献子类	Article
英文摘要	As a left-handed helical structure, Z-DNA is biologically active and it may be correlated with transcription and genome stability. Until recently, it remained a significant challenge to control the B/Z-DNA transition under physiological conditions. The current study represents the first to reversibly control B/Z-DNA transition using cucurbit[7]uril-based supramolecular approach. It is demonstrated that cucurbit[7]uril can encapsulate the central butanediamine moiety [HN(CH2)(4)NH] and reverses Z-DNA caused by spermine back to B-DNA. The subsequent treatment with 1-adamantanamine disassembles the cucurbit[7]uril/spermine complex and readily induces reconversion of B- into Z-DNA. The DNA conformational change is unequivocally demonstrated using different independent methods. Direct evidence for supramolecular interactions involved in DNA conformational changes is further provided. These findings can therefore open a new route to control DNA helical structure in a reversible way.
WOS关键词	HANDED Z-DNA ; BIOTIN-AVIDIN PAIR ; B-DNA ; CIRCULAR-DICHROISM ; BINDING ; PROTEIN ; SALT ; PORPHYRIN ; EXPRESSION ; AFFINITY
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	WILEY
WOS记录号	WOS:000439842100010
资助机构	National Science Foundation of China(21432008 ; National Science Foundation of China(21432008 ; 21722803 ; 21722803 ; 21721005 ; 21721005 ; 21672165 ; 21672165 ; 81373256 ; 81373256 ; 21372182 ; 21372182 ; 21472143) ; 21472143) ; National Science Foundation of China(21432008 ; National Science Foundation of China(21432008 ; 21722803 ; 21722803 ; 21721005 ; 21721005 ; 21672165 ; 21672165 ; 81373256 ; 81373256 ; 21372182 ; 21372182 ; 21472143) ; 21472143) ; National Science Foundation of China(21432008 ; National Science Foundation of China(21432008 ; 21722803 ; 21722803 ; 21721005 ; 21721005 ; 21672165 ; 21672165 ; 81373256 ; 81373256 ; 21372182 ; 21372182 ; 21472143) ; 21472143) ; National Science Foundation of China(21432008 ; National Science Foundation of China(21432008 ; 21722803 ; 21722803 ; 21721005 ; 21721005 ; 21672165 ; 21672165 ; 81373256 ; 81373256 ; 21372182 ; 21372182 ; 21472143) ; 21472143)
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/13034]
专题	中国科学院武汉物理与数学研究所
通讯作者	Wang, Shao-Ru; Zhou, Xiang
作者单位	1.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Key Lab Magnet Resonance Biol Syst, Wuhan 430071, Hubei, Peoples R China 2.Wuhan Univ, Minist Educ, Key Lab Biomed Polymers, Coll Chem & Mol Sci, Wuhan 430072, Hubei, Peoples R China 3.Wuhan Univ Sci & Technol, Coll Chem Engn & Technol, Wuhan 430081, Hubei, Peoples R China
推荐引用方式 GB/T 7714	Wang, Shao-Ru,Wang, Jia-Qi,Xu, Guo-Hua,et al. The Cucurbit[7]Uril-Based Supramolecular Chemistry for Reversible B/Z-DNA Transition[J]. ADVANCED SCIENCE,2018,5(7).
APA	Wang, Shao-Ru.,Wang, Jia-Qi.,Xu, Guo-Hua.,Wei, Lai.,Fu, Bo-Shi.,...&Zhou, Xiang.(2018).The Cucurbit[7]Uril-Based Supramolecular Chemistry for Reversible B/Z-DNA Transition.ADVANCED SCIENCE,5(7).
MLA	Wang, Shao-Ru,et al."The Cucurbit[7]Uril-Based Supramolecular Chemistry for Reversible B/Z-DNA Transition".ADVANCED SCIENCE 5.7(2018).