The caudal part of the posterior insula of rats participates in the maintenance but not the acquisition of morphine conditioned place preference

doi:10.1111/cns.12799

	The caudal part of the posterior insula of rats participates in the maintenance but not the acquisition of morphine conditioned place preference
	Sun, Yong-Mei 1,2,3; Chen, Rong-Xiang 4; Li, Zhi-Fei 1,2; Spijker, Sabine 3; Zhai, Rong-Wei 1,2; Yang, Shang-Chuan 1,2
刊名	CNS NEUROSCIENCE & THERAPEUTICS
	2018-05-01
卷号	24 期号:5 页码:420-428
关键词	Conditioned Place Preference Memory Maintenance Morphine Posterior Insula Somatosensory
ISSN号	1755-5930
DOI	10.1111/cns.12799
文献子类	Article
英文摘要	The heterogeneous insular cortex plays an interoceptive role in drug addiction by signaling the availability of drugs of abuse. Here, we tested whether the caudal part of the multisensory posterior insula (PI) stores somatosensory-associated rewarding memories. Using Sprague Dawley rats as subjects, we first established a morphine-induced conditioned place preference (CPP) paradigm, mainly based on somatic cues. Secondly, an electrolytic lesion of the caudal portion of the PI was carried out before and after the establishment of CPP, respectively. Our data demonstrated that the caudal PI lesions disrupted the maintenance, but not the acquisition of morphine-induced CPP. Lesion or subtle disruption of the PI had no major impact on locomotor activity. These findings indicate that the caudal portion of the PI might be involved in either the storage or the retrieval of morphine CPP memory.
WOS关键词	SECONDARY SOMATOSENSORY CORTEX ; BASOLATERAL AMYGDALA ; MEASURING REWARD ; DRUG-ADDICTION ; MEMORY ; INACTIVATION ; ORGANIZATION ; INHIBITION ; PARADIGM ; AVERSION
WOS研究方向	Neurosciences & Neurology ; Pharmacology & Pharmacy
语种	英语
出版者	WILEY
WOS记录号	WOS:000430058800006
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/12974]
专题	中国科学院武汉物理与数学研究所
通讯作者	Sun, Yong-Mei
作者单位	1.Chinese Acad Sci, Key Lab Anim Models & Human Dis Mechanisms, Kunming, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Zool, Kunming, Yunnan, Peoples R China 3.Vrije Univ Amsterdam, Dept Mol & Cellular Neurobiol, Ctr Neurogen & Cognit Res, Amsterdam Neurosci, Amsterdam, Netherlands 4.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Key Lab Magnet Resonance Biol Syst, Wuhan Inst Phys & Math, Wuhan, Hubei, Peoples R China
推荐引用方式 GB/T 7714	Sun, Yong-Mei,Chen, Rong-Xiang,Li, Zhi-Fei,et al. The caudal part of the posterior insula of rats participates in the maintenance but not the acquisition of morphine conditioned place preference[J]. CNS NEUROSCIENCE & THERAPEUTICS,2018,24(5):420-428.
APA	Sun, Yong-Mei,Chen, Rong-Xiang,Li, Zhi-Fei,Spijker, Sabine,Zhai, Rong-Wei,&Yang, Shang-Chuan.(2018).The caudal part of the posterior insula of rats participates in the maintenance but not the acquisition of morphine conditioned place preference.CNS NEUROSCIENCE & THERAPEUTICS,24(5),420-428.
MLA	Sun, Yong-Mei,et al."The caudal part of the posterior insula of rats participates in the maintenance but not the acquisition of morphine conditioned place preference".CNS NEUROSCIENCE & THERAPEUTICS 24.5(2018):420-428.