A Central Amygdala-Substantia Innominata Neural Circuitry Encodes Aversive Reinforcement Signals

doi:10.1016/j.celrep.2017.10.062

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 磁共振应用研究部

	A Central Amygdala-Substantia Innominata Neural Circuitry Encodes Aversive Reinforcement Signals
	Xu, Tonghui 1,2; Li, Haohong 1,2; Xu, Fuqiang 1,2,3,4; Gong, Hui 1,2; He, Xiaobin 3,4; Yuan, Jing 1,2; Peng, Jie 1,2; Jin, Sen 3,4; Lv, Guanghui 1,2; Cui, Yuting 1,2
刊名	CELL REPORTS
	2017-11-14
卷号	21 期号:7 页码:1770-1782
DOI	10.1016/j.celrep.2017.10.062
文献子类	Article
英文摘要	Aversive stimuli can impact motivation and support associative learning as reinforcers. However, the neural circuitry underlying the processing of aversive reinforcers has not been elucidated. Here, we report that a subpopulation of central amygdala (CeA) GABAergic neurons expressing protein kinase C-delta (PKC-delta+) displays robust responses to aversive stimuli during negative reinforcement learning. Importantly, projections from PKC-delta+ neurons of the CeA to the substantia innominata (SI) could bi-directionally modulate negative reinforcement learning. Moreover, consistent with the idea that SI-projecting PKC-delta+ neurons of the CeA encode aversive information, optogenetic activation of this pathway produces conditioned place aversion, a behavior prevented by simultaneous ablating of SI glutamatergic neurons. Taken together, our data define a cell-type-specific neural circuitry modulating associative learning by encoding aversive reinforcement signals.
WOS关键词	BASAL FOREBRAIN ; CONDITIONED FEAR ; INHIBITORY CIRCUITS ; RABIES VIRUS ; PASSIVE FEAR ; NEURONS ; PROJECTIONS ; PREDICTION ; BEHAVIORS ; NUCLEUS
WOS研究方向	Cell Biology
语种	英语
WOS记录号	WOS:000415073200007
资助机构	National Key Research and Development Program of China-Stem Cell and Translational Research(2016YFA0102500) ; National Key Research and Development Program of China-Stem Cell and Translational Research(2016YFA0102500) ; National Natural Science Foundation of China(91432107 ; National Natural Science Foundation of China(91432107 ; Science Fund for Creative Research Group of China(61421064) ; Science Fund for Creative Research Group of China(61421064) ; Director Fund of the Wuhan National Laboratory for Optoelectronics ; Director Fund of the Wuhan National Laboratory for Optoelectronics ; 31671105) ; 31671105) ; National Key Research and Development Program of China-Stem Cell and Translational Research(2016YFA0102500) ; National Key Research and Development Program of China-Stem Cell and Translational Research(2016YFA0102500) ; National Natural Science Foundation of China(91432107 ; National Natural Science Foundation of China(91432107 ; Science Fund for Creative Research Group of China(61421064) ; Science Fund for Creative Research Group of China(61421064) ; Director Fund of the Wuhan National Laboratory for Optoelectronics ; Director Fund of the Wuhan National Laboratory for Optoelectronics ; 31671105) ; 31671105)
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/11606]
专题	武汉物理与数学研究所_磁共振应用研究部
作者单位	1.Huazhong Univ Sci & Technol, Sch Engn Sci, MoE Key Lab Biomed Photon, Collaborat Innovat Ctr Biomed Engn, Wuhan 430074, Hubei, Peoples R China 2.Huazhong Univ Sci & Technol, Wuhan Natl Lab Optoelect, Britton Chance Ctr Biomed Photon, Wuhan 430074, Hubei, Peoples R China 3.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan, Hubei, Peoples R China 4.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Wuhan Inst Phys & Math, Ctr Brain Sci,Key Lab Magnet Resonance Biol Syst, Wuhan, Hubei, Peoples R China
推荐引用方式 GB/T 7714	Xu, Tonghui,Li, Haohong,Xu, Fuqiang,et al. A Central Amygdala-Substantia Innominata Neural Circuitry Encodes Aversive Reinforcement Signals[J]. CELL REPORTS,2017,21(7):1770-1782.
APA	Xu, Tonghui.,Li, Haohong.,Xu, Fuqiang.,Gong, Hui.,He, Xiaobin.,...&Cui, Yuting.(2017).A Central Amygdala-Substantia Innominata Neural Circuitry Encodes Aversive Reinforcement Signals.CELL REPORTS,21(7),1770-1782.
MLA	Xu, Tonghui,et al."A Central Amygdala-Substantia Innominata Neural Circuitry Encodes Aversive Reinforcement Signals".CELL REPORTS 21.7(2017):1770-1782.