Increasing Cancer Therapy Efficiency through Targeting and Localized Light Activation

doi:10.1021/acsami.7b05463

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 磁共振应用研究部

	Increasing Cancer Therapy Efficiency through Targeting and Localized Light Activation
	Li, Sha 2; Liu, Lianhua 2; Chen, Shizhen 2; Yang, Yuqi 2; Zhou, Xin 2; Liu, Maili 2; Bouchard, Louis-S.1,3; Zhang, Zhiying 2; Li, Haidong 2; Zhao, Xiuchao 2
刊名	ACS APPLIED MATERIALS & INTERFACES
	2017-07-19
卷号	9 期号:28 页码:23400-23408
关键词	Photodynamic Therapy Biological Redox Therapy Photothermal Therapy Graphene Quantum Dots Dual-modality Imaging
DOI	10.1021/acsami.7b05463
文献子类	Article
英文摘要	Currently, the potential of cancer therapy is compromised by a variety of problems related to tumor specificity, drug access, and limited efficacy. We report a novel approach to improve the effectiveness of cancer treatment utilizing a light-responsive nanoconstruct. Effectiveness is increased by enhancing drug absorption through heating and the production of free radicals. Treatment specificity is increased through chemical targeting of the nanoconstruct and localization of light delivery to the tumor. When reaching the tumor, magnetic resonance imaging is enhanced and near-infrared fluorescence is activated upon drug release, making it possible to visualize the localized treatment at both the tissue and cellular levels. This dual-modality imaging nanoconstruct enables the synergistic treatment and observable evaluation of solid tumors with dramatically improved efficacy, giving rise to a promising new approach for cancer therapy and evaluation.
WOS关键词	GRAPHENE QUANTUM DOTS ; PHOTODYNAMIC THERAPY ; ANTITUMOR IMMUNITY ; NANOPARTICLES ; SENSITIVITY ; GADOLINIUM ; AGENT ; CELLS ; DRUG
WOS研究方向	Science & Technology - Other Topics ; Materials Science
语种	英语
WOS记录号	WOS:000406172700014
资助机构	National Natural Science Foundation of China(21605158 ; National Natural Science Foundation of China(21605158 ; National Program for Special Support of Eminent Professionals (National Program for Support of Top-notch Young Professionals) ; National Program for Special Support of Eminent Professionals (National Program for Support of Top-notch Young Professionals) ; 21575157 ; 21575157 ; 81227902) ; 81227902) ; National Natural Science Foundation of China(21605158 ; National Natural Science Foundation of China(21605158 ; National Program for Special Support of Eminent Professionals (National Program for Support of Top-notch Young Professionals) ; National Program for Special Support of Eminent Professionals (National Program for Support of Top-notch Young Professionals) ; 21575157 ; 21575157 ; 81227902) ; 81227902)
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/11320]
专题	武汉物理与数学研究所_磁共振应用研究部
作者单位	1.Univ Calif Los Angeles, Dept Bioengn, Jonsson Comprehens Canc Ctr, Calif NanoSyst Inst,Mol Biol Inst, Los Angeles, CA 90095 USA 2.Chinese Acad Sci, Key Lab Magnet Resonance Biol Syst, State Key Lab Magnet Resonance & Atom & Mol Phys, Natl Ctr Magnet Resonance Wuhan,Wuhan Inst Phys &, Wuhan 430071, Peoples R China 3.Univ Calif Los Angeles, Dept Chem & Biochem, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90095 USA
推荐引用方式 GB/T 7714	Li, Sha,Liu, Lianhua,Chen, Shizhen,et al. Increasing Cancer Therapy Efficiency through Targeting and Localized Light Activation[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(28):23400-23408.
APA	Li, Sha.,Liu, Lianhua.,Chen, Shizhen.,Yang, Yuqi.,Zhou, Xin.,...&Zen, Qingbin.(2017).Increasing Cancer Therapy Efficiency through Targeting and Localized Light Activation.ACS APPLIED MATERIALS & INTERFACES,9(28),23400-23408.
MLA	Li, Sha,et al."Increasing Cancer Therapy Efficiency through Targeting and Localized Light Activation".ACS APPLIED MATERIALS & INTERFACES 9.28(2017):23400-23408.