Reactive Oxygen Species and Glutathione Dual Redox-Responsive Supramolecular Assemblies with Controllable Release Capability

doi:10.1021/acsami.6b14640

	Reactive Oxygen Species and Glutathione Dual Redox-Responsive Supramolecular Assemblies with Controllable Release Capability
	Ding, LS; Kang, Y; Zhang, S (reprint author), Sichuan Univ, Polymer Res Inst, State Key Lab Polymer Mat Engn, Chengdu 610065, Sichuan, Peoples R China.; Li, BJ (reprint author), Chinese Acad Sci, Chengdu Inst Biol, Key Lab Mt Ecol Restorat & Bioresource Utilizat, Chengdu 610041, Sichuan, Peoples R China.; Li, BJ; Zhang, S; Ju, X
刊名	ACS APPLIED MATERIALS & INTERFACES
	2017
卷号	9 期号:5 页码:4475-4484
关键词	Supramolecular Redox-responsive Self-assembly Micelles Drug Carrier
DOI	10.1021/acsami.6b14640
产权排序	1
文献子类	Article
英文摘要	A dual redox and biorelevant triggered supramolecular system is developed through noncovalent supramolecular inclusion interactions between the ferrocene (Fc) modified on camptothecin (CPT) and beta-cyclodextrin (beta-CD) at the end of methoxy polyethylene glycol (mPEG). With these two segments, a stable noncovalent supramolecular structure, i.e., mPEG-beta-CD/Fc-CPT, can be formed, and then self-assembled into micellar structures in water. Interestingly, these supramolecular micelles showed uniform sphere structure, high and constant drug loading content, hyper-fast redox-responsive drug release, and exhibited equal cellular proliferation inhibition toward A549 cancer cells. The cytotoxicity evaluation of mPEG-beta-CD also indicated good biocompatibility. In vivo results revealed the mPEG-beta-CD/Fc-CPT nanoparticles had higher in vivo efficacy without side effects. It is anticipated this supramolecular complex may serve as a new kind of promising alternative for drug delivery systems.
学科主题	Science & Technology - Other Topics ; Materials Science
项目编号	中国科学院山地生态恢复与生物资源利用重点实验室
语种	英语
资助机构	All authors received funding from National Natural Science Foundation of China (Grant Nos. 51573187, 51373174), West Light Foundation of CAS. ; National Natural Science Foundation of China [51573187, 51373174] ; All authors received funding from National Natural Science Foundation of China (Grant Nos. 51573187, 51373174), West Light Foundation of CAS. ; National Natural Science Foundation of China [51573187, 51373174] ; West Light Foundation of CAS ; West Light Foundation of CAS ; All authors received funding from National Natural Science Foundation of China (Grant Nos. 51573187, 51373174), West Light Foundation of CAS. ; National Natural Science Foundation of China [51573187, 51373174] ; All authors received funding from National Natural Science Foundation of China (Grant Nos. 51573187, 51373174), West Light Foundation of CAS. ; National Natural Science Foundation of China [51573187, 51373174] ; West Light Foundation of CAS ; West Light Foundation of CAS
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/29252]
专题	成都生物研究所_天然产物研究
通讯作者	Zhang, S (reprint author), Sichuan Univ, Polymer Res Inst, State Key Lab Polymer Mat Engn, Chengdu 610065, Sichuan, Peoples R China.; Li, BJ (reprint author), Chinese Acad Sci, Chengdu Inst Biol, Key Lab Mt Ecol Restorat & Bioresource Utilizat, Chengdu 610041, Sichuan, Peoples R China.
推荐引用方式 GB/T 7714	Ding, LS,Kang, Y,Zhang, S ,et al. Reactive Oxygen Species and Glutathione Dual Redox-Responsive Supramolecular Assemblies with Controllable Release Capability[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(5):4475-4484.
APA	Ding, LS.,Kang, Y.,Zhang, S .,Li, BJ .,Li, BJ.,...&Ju, X.(2017).Reactive Oxygen Species and Glutathione Dual Redox-Responsive Supramolecular Assemblies with Controllable Release Capability.ACS APPLIED MATERIALS & INTERFACES,9(5),4475-4484.
MLA	Ding, LS,et al."Reactive Oxygen Species and Glutathione Dual Redox-Responsive Supramolecular Assemblies with Controllable Release Capability".ACS APPLIED MATERIALS & INTERFACES 9.5(2017):4475-4484.