Pharmaceutical Intermediate-Modified Gold Nanoparticles: Against Multidrug-Resistant Bacteria and Wound-Healing Application via an Electrospun Scaffold

doi:10.1021/acsnano.7b01240

	Pharmaceutical Intermediate-Modified Gold Nanoparticles: Against Multidrug-Resistant Bacteria and Wound-Healing Application via an Electrospun Scaffold
	Yang, XL; Jiang, XY; Shao, HW; Shao, HW (reprint author), Chinese Acad Sci, Chengdu Inst Biol, Nat Prod Res Ctr, Chengdu 610041, Sichuan, Peoples R China.; Jiang, XY (reprint author), Natl Ctr NanoSci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China.; Zhang, LM; Yang, G; Jia, YX; Ran, B; Wang, L
刊名	ACS NANO
	2017
卷号	11 期号:6 页码:5737-5745
关键词	Gold Nanoparticles Pharmaceutical Intermediate Antibacterial Activity Electrospun Nanofibers Wound Healing
DOI	10.1021/acsnano.7b01240
产权排序	1
文献子类	Article
英文摘要	Remedying a multidrug-resistant (MDR) bacteria wound infection is a major challenge due to the inability of conventional antibiotics to treat such infections against MDR bacteria. Thus, developing wound dressings for wound care, particularly against MDR bacteria, is in huge demand. Here, we present a strategy in designing wound dressings: we use a small molecule (6-aminopenicillanic acid, APA)-coated gold nanoparticles (AuNPs) to inhibit MDR bacteria. We dope the AuNPs into electrospun fibers of poly(epsilon-caprolactone) (PCL)/gelatin to yield materials that guard against wound infection by MDR bacteria. We systematically evaluate the bactericidal activity of the AuNPs and wound-healing capability via the electrospun scaffold. APA-modified AuNPs (Au_APA) exhibit remarkable antibacterial activity even when confronted with MDR bacteria. Meanwhile, Au_APA has outstanding biocompatibility. Moreover, an in vivo bacteria-infected wound-healing experiment indicates that it has a striking ability to remedy a MDR bacteria wound infection. This wound scaffold can assist the wound care for bacterial infections.
学科主题	Chemistry ; Science & Technology - Other Topics ; Materials Science
语种	英语
资助机构	We thank the Ministry of Science and Technology of China (2013YQ190467), Chinese Academy of Sciences (XDA09030305) and the National Science Foundation of China (81361140345, 51373043, 21535001) for financial support. ; Ministry of Science and Technology of China [2013YQ190467] ; We thank the Ministry of Science and Technology of China (2013YQ190467), Chinese Academy of Sciences (XDA09030305) and the National Science Foundation of China (81361140345, 51373043, 21535001) for financial support. ; Ministry of Science and Technology of China [2013YQ190467] ; Chinese Academy of Sciences [XDA09030305] ; Chinese Academy of Sciences [XDA09030305] ; National Science Foundation of China [81361140345, 51373043, 21535001] ; National Science Foundation of China [81361140345, 51373043, 21535001] ; We thank the Ministry of Science and Technology of China (2013YQ190467), Chinese Academy of Sciences (XDA09030305) and the National Science Foundation of China (81361140345, 51373043, 21535001) for financial support. ; Ministry of Science and Technology of China [2013YQ190467] ; We thank the Ministry of Science and Technology of China (2013YQ190467), Chinese Academy of Sciences (XDA09030305) and the National Science Foundation of China (81361140345, 51373043, 21535001) for financial support. ; Ministry of Science and Technology of China [2013YQ190467] ; Chinese Academy of Sciences [XDA09030305] ; Chinese Academy of Sciences [XDA09030305] ; National Science Foundation of China [81361140345, 51373043, 21535001] ; National Science Foundation of China [81361140345, 51373043, 21535001]
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/29235]
专题	成都生物研究所_天然产物研究
通讯作者	Shao, HW (reprint author), Chinese Acad Sci, Chengdu Inst Biol, Nat Prod Res Ctr, Chengdu 610041, Sichuan, Peoples R China.; Jiang, XY (reprint author), Natl Ctr NanoSci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China.
推荐引用方式 GB/T 7714	Yang, XL,Jiang, XY,Shao, HW,et al. Pharmaceutical Intermediate-Modified Gold Nanoparticles: Against Multidrug-Resistant Bacteria and Wound-Healing Application via an Electrospun Scaffold[J]. ACS NANO,2017,11(6):5737-5745.
APA	Yang, XL.,Jiang, XY.,Shao, HW.,Shao, HW .,Jiang, XY .,...&Yang, JC.(2017).Pharmaceutical Intermediate-Modified Gold Nanoparticles: Against Multidrug-Resistant Bacteria and Wound-Healing Application via an Electrospun Scaffold.ACS NANO,11(6),5737-5745.
MLA	Yang, XL,et al."Pharmaceutical Intermediate-Modified Gold Nanoparticles: Against Multidrug-Resistant Bacteria and Wound-Healing Application via an Electrospun Scaffold".ACS NANO 11.6(2017):5737-5745.