Cucurbitane glycosides from the fruit of Siraitia grosvenori and their effects on glucose uptake in human HepG2 cells in vitro

doi:10.1016/j.foodchem.2017.02.018

	Cucurbitane glycosides from the fruit of Siraitia grosvenori and their effects on glucose uptake in human HepG2 cells in vitro
	Li, F; Yang, FM; Liu, X; Wang, L; Chen, B; Li, LH; Wang, MK; Wang, MK (reprint author), Chinese Acad Sci, Key Lab Mt Ecol Restorat & Bioresource Utilizat, Chengdu Inst Biol, Chengdu 610041, Peoples R China.; Wang, MK (reprint author), Chinese Acad Sci, Ecol Restorat Biodivers Conservat Key Lab Sichuan, Chengdu Inst Biol, Chengdu 610041, Peoples R China.
刊名	FOOD CHEMISTRY
	2017
卷号	228 页码:567-573
关键词	Siraitia Grosvenori Cucurbitane Glycosides Glucose Uptake In Vitro
DOI	10.1016/j.foodchem.2017.02.018
产权排序	2
文献子类	Article
英文摘要	The mogrosides in the fruit of Siraitia grosvenori can serve as a sugar substitute for diabetics due to their sweetness, low calorie and positive effects on blood glucose level control. The present study was to purify the mogrosides from the fruit of S. grosvenori and evaluate their enhancement of glucose uptake rate in HepG2 cells in vitro. As a result, eighteen mogrosides were isolated, including six new ones and a known but new naturally occurring compound. The chemical structures of the new compounds were identified by 1D, 2D-NMR and HR-ESI-MS techniques, together with chemical methods. Compared to the positive control (metformin), all the obtained mogrosides showed equivalent or more potent effects on the glucose uptake in HepG2 cells in vitro. These results suggested the mogrosides in the fruit of S. grosvenori were worthy of further research to confirm their potential benefits for obese and diabetic patients. (C) 2017 Elsevier Ltd. All rights reserved.
学科主题	Chemistry ; Food Science & Technology ; Nutrition & Dietetics
项目编号	中国科学院山地生态恢复与生物资源利用重点实验室
语种	英语
资助机构	This work was supported by the Key Research Program of the Chinese Academy of Sciences under grant (No. KSZD-EW-Z-004); the National Natural Science Foundation of China under grant (No. 21561142003). ; Key Research Program of the Chinese Academy of Sciences [KSZD-EW-Z-004] ; This work was supported by the Key Research Program of the Chinese Academy of Sciences under grant (No. KSZD-EW-Z-004); the National Natural Science Foundation of China under grant (No. 21561142003). ; Key Research Program of the Chinese Academy of Sciences [KSZD-EW-Z-004] ; National Natural Science Foundation of China [21561142003] ; National Natural Science Foundation of China [21561142003] ; This work was supported by the Key Research Program of the Chinese Academy of Sciences under grant (No. KSZD-EW-Z-004); the National Natural Science Foundation of China under grant (No. 21561142003). ; Key Research Program of the Chinese Academy of Sciences [KSZD-EW-Z-004] ; This work was supported by the Key Research Program of the Chinese Academy of Sciences under grant (No. KSZD-EW-Z-004); the National Natural Science Foundation of China under grant (No. 21561142003). ; Key Research Program of the Chinese Academy of Sciences [KSZD-EW-Z-004] ; National Natural Science Foundation of China [21561142003] ; National Natural Science Foundation of China [21561142003]
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/29221]
专题	成都生物研究所_天然产物研究
通讯作者	Wang, MK (reprint author), Chinese Acad Sci, Key Lab Mt Ecol Restorat & Bioresource Utilizat, Chengdu Inst Biol, Chengdu 610041, Peoples R China.; Wang, MK (reprint author), Chinese Acad Sci, Ecol Restorat Biodivers Conservat Key Lab Sichuan, Chengdu Inst Biol, Chengdu 610041, Peoples R China.
推荐引用方式 GB/T 7714	Li, F,Yang, FM,Liu, X,et al. Cucurbitane glycosides from the fruit of Siraitia grosvenori and their effects on glucose uptake in human HepG2 cells in vitro[J]. FOOD CHEMISTRY,2017,228:567-573.
APA	Li, F.,Yang, FM.,Liu, X.,Wang, L.,Chen, B.,...&Wang, MK .(2017).Cucurbitane glycosides from the fruit of Siraitia grosvenori and their effects on glucose uptake in human HepG2 cells in vitro.FOOD CHEMISTRY,228,567-573.
MLA	Li, F,et al."Cucurbitane glycosides from the fruit of Siraitia grosvenori and their effects on glucose uptake in human HepG2 cells in vitro".FOOD CHEMISTRY 228(2017):567-573.