A New Triterpene and an Antiarrhythmic Liriodendrin from Pittosporum brevicalyx

	A New Triterpene and an Antiarrhythmic Liriodendrin from Pittosporum brevicalyx
	Feng, Chun; Li, Bo-Gang; Gao, Xiao-Ping; Qi, Hua-Yi; Zhang, Guo-Lin; Zhang, GL, Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China
刊名	ARCHIVES OF PHARMACAL RESEARCH
	2010
卷号	33 期号:12 页码:1927-1932
关键词	Pittosporum Brevicalyx Liriodendrin Antiarrhythmic Cacl2-induced Arrhythmias
ISSN号	0253-6269
产权排序	1
英文摘要	A new triterpene, 21-O-senecioyl-R-1-barrigenol (1) and 13 known compounds were isolated from the ethanol extracts of the leaves and bark of Pittosporum brevicalyx (Oliv.) Gagnep. Their structures were elucidated based on spectral data. The antiarrhythmic action of one furofuran lignan, liriodendrin (2), was tested on a model of CaCl2-induced arrhythmia and compared with the effect of verapamil. The prophylactic administration of liriodendrin (2) was effective in prolonging latency of arrhythmia and reducing the occurrence of ventricular fibrillation from 75% to 25%. The overall mortality rate was significantly reduced by the prophylactic administration of liriodendrin from 87.5% to 25%. The antiarrhythmic effect of liriodendrin (5.0 mg/kg) was similar to that of verapamil (1.05 mg/kg). Thus, liriodendrin may be a potent suppressor of CaCl2-induced arrhythmias.
学科主题	Chemistry, Medicinal ; Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000285794800007
资助机构	Di-Ao Pharmaceutical Group in Chengdu ; Di-Ao Pharmaceutical Group in Chengdu ; Di-Ao Pharmaceutical Group in Chengdu ; Di-Ao Pharmaceutical Group in Chengdu
公开日期	2011-07-08
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/18359]
专题	成都生物研究所_天然产物研究
通讯作者	Zhang, GL, Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China
推荐引用方式 GB/T 7714	Feng, Chun,Li, Bo-Gang,Gao, Xiao-Ping,et al. A New Triterpene and an Antiarrhythmic Liriodendrin from Pittosporum brevicalyx[J]. ARCHIVES OF PHARMACAL RESEARCH,2010,33(12):1927-1932.
APA	Feng, Chun,Li, Bo-Gang,Gao, Xiao-Ping,Qi, Hua-Yi,Zhang, Guo-Lin,&Zhang, GL, Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China.(2010).A New Triterpene and an Antiarrhythmic Liriodendrin from Pittosporum brevicalyx.ARCHIVES OF PHARMACAL RESEARCH,33(12),1927-1932.
MLA	Feng, Chun,et al."A New Triterpene and an Antiarrhythmic Liriodendrin from Pittosporum brevicalyx".ARCHIVES OF PHARMACAL RESEARCH 33.12(2010):1927-1932.