In vitro synergistic antibacterial activities of helvolic acid on multi-drug resistant Staphylococcus aureus | |
Qin, L; Li, BG; Guan, JF; Zhang, GL; Zhang, GL, Chinese Acad Sci, Chengdu Inst Biol, Chengdu, Peoples R China. | |
刊名 | NATURAL PRODUCT RESEARCH |
2009 | |
卷号 | 23期号:4页码:309_318 |
关键词 | Helvolic Acid Synergistic Effect Multi-drug Resistance Staphylococcus Aureus |
ISSN号 | 1478-6419 |
产权排序 | 1 |
英文摘要 | An agar plate method was established to screen synergistic antibacterial agents other than -lactamase inhibitors. By using this method, a strain Aspergillus sp136 was selected for further studies. From the metabolites of this strain, a synergistic antibacterial compound was isolated by bioautographic TLC assay-guided fractionation and identified as helvolic acid. The synergistic effect of helvolic acid to penicillin was about 3 times that of clavulanic acid to penicillin in agar diffusion assay on Bacillus cereus. In checkerboard studies, helvolic acid exhibited synergistic effects with erythromycin on all tested multi-drug resistant Staphylococcus aureus and with penicillin and tetracycline on some multi-drug resistant S. aureus. A pattern of enhanced killing was also found in time-kill studies on multi-drug resistant S. aureus. |
学科主题 | Chemistry, Applied ; Chemistry, Medicinal |
语种 | 英语 |
WOS记录号 | WOS:000264337700001 |
公开日期 | 2011-07-08 |
内容类型 | 期刊论文 |
源URL | [http://210.75.237.14/handle/351003/18249] |
专题 | 成都生物研究所_天然产物研究 |
通讯作者 | Zhang, GL, Chinese Acad Sci, Chengdu Inst Biol, Chengdu, Peoples R China. |
推荐引用方式 GB/T 7714 | Qin, L,Li, BG,Guan, JF,et al. In vitro synergistic antibacterial activities of helvolic acid on multi-drug resistant Staphylococcus aureus[J]. NATURAL PRODUCT RESEARCH,2009,23(4):309_318. |
APA | Qin, L,Li, BG,Guan, JF,Zhang, GL,&Zhang, GL, Chinese Acad Sci, Chengdu Inst Biol, Chengdu, Peoples R China..(2009).In vitro synergistic antibacterial activities of helvolic acid on multi-drug resistant Staphylococcus aureus.NATURAL PRODUCT RESEARCH,23(4),309_318. |
MLA | Qin, L,et al."In vitro synergistic antibacterial activities of helvolic acid on multi-drug resistant Staphylococcus aureus".NATURAL PRODUCT RESEARCH 23.4(2009):309_318. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论