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	Biomedical PTFE after Plasma Treatment and the Surface Functionalization with Biomolecules for Vascular Graft
	Huaiyu Wang; Ang Gao; Liping Tong
	2017
会议日期	2017
会议地点	希腊雅典
英文摘要	Small diameter vascular grafts made of biomedical polytetrafluoroethylene (PTFE) suffer from the poor long-term patency rate because of the thrombosis and intimal hyperplasia, which are ascribed to the insufficient endothelialization and chronic inflammation of PTFE itself. Therefore, grafts with reduced thrombogenicity, rapid endothelialization, as well as low inflammatory immune response are highly desirable. In this work, biomedical PTFE is initially modified by plasma immersion ion implantation (PIII). After N2 PIII treatment, the surface of biomedical PTFE is roughed with nanostructure and more importantly, abundant free radicals are generated underneath the surface, which continuously migrate to the surface and react with the environmental molecules. Taking advantage of this mechanism, various biomolecules with different functions can be steadily immobilized on the surface of PTFE by simple solution immersion. In particular, biomolecules such as heparin, SDF-1α and CD47 can be covalently grafted on the surface of PTFE undergoing N2 PIII without compromising their bioactivity. As a result, the surface-functionalized PTFE can reduce thrombogenicity, facilitate endothelial progenitor cells recruitment, and mitigate the inflammatory immune response, hence is promising for fabricating small diameter vascular grafts with good long-term patency.
语种	英语
内容类型	会议论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/12414]
专题	深圳先进技术研究院_医药所
作者单位	2017
推荐引用方式 GB/T 7714	Huaiyu Wang,Ang Gao,Liping Tong. Biomedical PTFE after Plasma Treatment and the Surface Functionalization with Biomolecules for Vascular Graft[C]. 见:. 希腊雅典. 2017.

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