Immunotherapy Targeting Adenosine Synthase A Decreases Severity of Staphylococcus aureus Infection in Mouse Model.

	Immunotherapy Targeting Adenosine Synthase A Decreases Severity of Staphylococcus aureus Infection in Mouse Model.
	Lin, Qiubin ; Huang, Jian-Dong; Yuen, Kwok-Yung ; Sze, Konghung ; Kao, Richard Yi-Tsun ; Zheng, SongYue ; Xu, Chen ; Yang, Xiao-Yan ; Xiong, Lifeng ; Yu, Bin
刊名	JOURNAL OF INFECTIOUS DISEASES
	2017
文献子类	期刊论文
英文摘要	Staphylococcus aureus is a severe pathogen found in the community and in hospitals. Most notably, methicillin-resistant S. aureus (MRSA) is resistant to almost all antibiotics, which is a growing public health concern. The emergence of drug-resistant strains has prompted the search for alternative treatments such as immunotherapeutic approaches. Previous research showed that S. aureus exploit the immunomodulatory attributes of adenosine to escape host immunity. In this study, we investigated adenosine synthase A (AdsA), an S. aureus cell wall-anchored enzyme as possible targets for immunotherapy. Mice vaccinated with aluminum hydroxide-formulated recombinant AdsA (rAdsA) induced high-titer anti-AdsA antibodies, thereby providing consistent protection in 3 mouse infection models when challenged with 2 S. aureus strains. The importance of anti-AdsA antibody in protection was demonstrated by passive transfer experiments. Moreover, AdsA-specific antisera promote killing S. aureus by immune cells. Altogether, our data demonstrate that the AdsA is a promising target for vaccines and therapeutics development to alleviate severe S. aureus diseases.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/12329]
专题	深圳先进技术研究院_医药所
作者单位	JOURNAL OF INFECTIOUS DISEASES
推荐引用方式 GB/T 7714	Lin, Qiubin , Huang, Jian-Dong, Yuen, Kwok-Yung ,et al. Immunotherapy Targeting Adenosine Synthase A Decreases Severity of Staphylococcus aureus Infection in Mouse Model.[J]. JOURNAL OF INFECTIOUS DISEASES,2017.
APA	Lin, Qiubin ., Huang, Jian-Dong., Yuen, Kwok-Yung ., Sze, Konghung ., Kao, Richard Yi-Tsun .,...&Zhang, Bao-Zhong .(2017).Immunotherapy Targeting Adenosine Synthase A Decreases Severity of Staphylococcus aureus Infection in Mouse Model..JOURNAL OF INFECTIOUS DISEASES.
MLA	Lin, Qiubin ,et al."Immunotherapy Targeting Adenosine Synthase A Decreases Severity of Staphylococcus aureus Infection in Mouse Model.".JOURNAL OF INFECTIOUS DISEASES (2017).