Adipose-specific deletion of Kif5b exacerbates obesity and insulin resistance in a mouse model of diet-induced obesity.

	Adipose-specific deletion of Kif5b exacerbates obesity and insulin resistance in a mouse model of diet-induced obesity.
	Wang, Zai; Li, Yun-Xuan; Wang, Zhen-He; Gong, Huan; Lin, Ya-Jun; Pang, Jing; Cui, Ju; Huang, Jian-Dong; Jiang, Ping; Li, Jin
刊名	FASEB JOURNAL
	2017
文献子类	期刊论文
英文摘要	Recent studies haveshownthatKIF5B (conventionalkinesin heavy chain) mediates glucose transporter type 4 translocation and adiponectin secretion in 3T3-L1 adipocytes, suggesting an involvement of KIF5B in the homeostasis of metabolism. However, the in vivo physiologic function ofKIF5B in adipose tissue remains to be determined. In this study, adipose-specific Kif5b knockout (F-K5bKO) mice were generated using the Cre-LoxP strategy. F-K5bKO mice had similar body weights to controls fed on a standard chow diet. However, F-K5bKO mice had hyperlipidemia and significant glucose intolerance and insulin resistance.Deletion of Kif5b aggravated the deleterious impact of a high-fat diet (HFD) on body weight gain, hepatosteatosis, glucose tolerance, and systematic insulinsensitivity. These changes were accompanied by impaired insulin signaling, decreased secretion of adiponectin, and increased serum levels of leptin and proinflammatory adipokines. F-K5bKO mice fed on an HFD exhibited lower energy expenditure and thermogenic dysfunction as a result of whitening of brown adipose due to decreased mitochondria biogenesis and down regulation of key thermogenicgene expression. In conclusion, selective deletion of Kif5b inadipose tissue exacerbates HFD-induced obesity and its associated metabolic disorders, partly through a decrease in energy expenditure, dysregulation ofadipokine secretion, and insulin signaling.-Cui, J., Pang, J., Lin, Y.-J., Gong, H., Wang, Z.-H., Li, Y.-X., Li, J., Wang, Z., Jiang, P., Dai, D.-P., Li, J., Cai, J.-P., Huang, J.-D., Zhang, T.-M. Adipose-specific deletionof Kif5b exacerbates obesity and insulin resistance in a mousemodel of diet-induced obesity.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/12327]
专题	深圳先进技术研究院_医药所
作者单位	FASEB JOURNAL
推荐引用方式 GB/T 7714	Wang, Zai,Li, Yun-Xuan,Wang, Zhen-He,et al. Adipose-specific deletion of Kif5b exacerbates obesity and insulin resistance in a mouse model of diet-induced obesity.[J]. FASEB JOURNAL,2017.
APA	Wang, Zai.,Li, Yun-Xuan.,Wang, Zhen-He.,Gong, Huan.,Lin, Ya-Jun.,...&Dai, Da-Peng.(2017).Adipose-specific deletion of Kif5b exacerbates obesity and insulin resistance in a mouse model of diet-induced obesity..FASEB JOURNAL.
MLA	Wang, Zai,et al."Adipose-specific deletion of Kif5b exacerbates obesity and insulin resistance in a mouse model of diet-induced obesity.".FASEB JOURNAL (2017).