Electrospun Photocrosslinkable Hydrogel Fibrous Scaffolds for Rapid In Vivo Vascularized Skin Flap Regeneration.

	Electrospun Photocrosslinkable Hydrogel Fibrous Scaffolds for Rapid In Vivo Vascularized Skin Flap Regeneration.
	Cui, Wenguo; Zhao, Xin; Pan, Guoqing; Zhang, Ying; Cheng, Liying; Zhang, Hongbo; Lang, Qi; Sun, Xiaoming; Zhang, Yuguang; Santos, Helder A.
刊名	ADVANCED FUNCTIONAL MATERIALS
	2017
文献子类	期刊论文
英文摘要	Distal necrosis of random skin flap is always clinical problematic in plastic surgery. The development of 3D functional vascular networks is fundamental for the survival of a local random skin flap. Herein, an effective technique on constructing 3D fibrous scaffolds for accelerated vascularization is demonstrated using a photocrosslinkable natural hydrogel based on gelatin methacryloyl (GelMA) by electrospinning. It is found that the ultraviolet (UV) photocrosslinkable gelatin electrospun hydrogel fibrous membranes exhibit soft adjustable mechanical properties and controllable degradation properties. Furthermore, it is observed that the optimized hydrogel scaffolds can support endothelial cells and dermal fibroblasts adhesion, proliferation, and migration into the scaffolds, which facilitates vascularization. Importantly, a rapid formation of tubes is observed after 3 d seeding of endothelial cells. After GelMA fibrous scaffold implantation below the skin flap in a rat model, it is found that the flap survival rate is higher than the control group, and there is more microvascular formation, which is potentially beneficial for the flap tissue vascularization. These data suggest that GelMA hydrogels can be used for biomedical applications that require the formation of microvascular networks, including the development of complex engineered tissues.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/12321]
专题	深圳先进技术研究院_医药所
作者单位	ADVANCED FUNCTIONAL MATERIALS
推荐引用方式 GB/T 7714	Cui, Wenguo,Zhao, Xin,Pan, Guoqing,et al. Electrospun Photocrosslinkable Hydrogel Fibrous Scaffolds for Rapid In Vivo Vascularized Skin Flap Regeneration.[J]. ADVANCED FUNCTIONAL MATERIALS,2017.
APA	Cui, Wenguo.,Zhao, Xin.,Pan, Guoqing.,Zhang, Ying.,Cheng, Liying.,...&Yang, Huilin.(2017).Electrospun Photocrosslinkable Hydrogel Fibrous Scaffolds for Rapid In Vivo Vascularized Skin Flap Regeneration..ADVANCED FUNCTIONAL MATERIALS.
MLA	Cui, Wenguo,et al."Electrospun Photocrosslinkable Hydrogel Fibrous Scaffolds for Rapid In Vivo Vascularized Skin Flap Regeneration.".ADVANCED FUNCTIONAL MATERIALS (2017).