2D Material-Based Nanofibrous Membrane for Photothermal Cancer Therapy.

	2D Material-Based Nanofibrous Membrane for Photothermal Cancer Therapy.
	Qian Luo; Paul K. Chu; Xue-Feng Yu; Wenhua Zhou; Huaiyu Wang; Hanhan Xie; Jundong Shao
刊名	ACS APPLIED MATERIALS & INTERFACES
	2017
文献子类	期刊论文
英文摘要	One of the clinical challenges facing photothermal cancer therapy is health risks imposed by the photothermal nanoagents in vivo. Herein, a photothermal therapy (PTT) platform composed of a 2D material-based nanofibrous membrane as the agent to deliver thermal energy to tumors under near-infrared (NIR) light irradiation is described. The photothermal membrane, which is fabricated by an electrospinning poly(l-lactic acid) (PLLA) nanofibrous membrane loaded with bismuth selenide (Bi2Se3) nanoplates, exhibits very high photothermal conversion efficiency and long-term stability. Cell experiments and hematological analyses demonstrate that the Bi2Se3/PLLA membranes have excellent biocompatibility and low toxicity. PTT experiments performed in vivo with the Bi2Se3/PLLA membrane covering the tumor and NIR irradiation produce local hyperthermia to ablate the tumor with high efficiency. Different from the traditional systematical and local injection techniques, this membrane-based PTT platform is promising in photothermal cancer therapy, especially suitable for the treatment of multiple solid tumors or skin cancers, and long-term prevention of cancer recurrence after surgery or PTT, while eliminating the health hazards of nanoagents.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/12318]
专题	深圳先进技术研究院_医药所
作者单位	ACS APPLIED MATERIALS & INTERFACES
推荐引用方式 GB/T 7714	Qian Luo,Paul K. Chu,Xue-Feng Yu,et al. 2D Material-Based Nanofibrous Membrane for Photothermal Cancer Therapy.[J]. ACS APPLIED MATERIALS & INTERFACES,2017.
APA	Qian Luo.,Paul K. Chu.,Xue-Feng Yu.,Wenhua Zhou.,Huaiyu Wang.,...&Jundong Shao.(2017).2D Material-Based Nanofibrous Membrane for Photothermal Cancer Therapy..ACS APPLIED MATERIALS & INTERFACES.
MLA	Qian Luo,et al."2D Material-Based Nanofibrous Membrane for Photothermal Cancer Therapy.".ACS APPLIED MATERIALS & INTERFACES (2017).