MiRNA-194 activates the Wnt/beta-catenin signaling pathway in gastric cancer by targeting the negative Wnt regulator, SUFU.

	MiRNA-194 activates the Wnt/beta-catenin signaling pathway in gastric cancer by targeting the negative Wnt regulator, SUFU.
	Fan, Xinmin; Peng, Yin; Zhang, Xiaojing; Ma, Qiang; Yan, Ruibin; Qin, Ying; Zhao, Yanqiu; Cheng, Yulan; Yang, Mengting; Wang, Qixiang
刊名	CANCER LETTERS
	2017
文献子类	期刊论文
英文摘要	Emerging evidence has shown that miRNA-194 is aberrantly upregulated in gastric cancer (GC); however, the biological mechanisms underlying its involvement are largely unknown. Wnt/beta-catenin signaling has been implicated in gastric tumorigenesis; we therefore hypothesized that miRNA-194promotes gastric carcinogenesis by activating Wnt/beta-catenin signaling. MiRNA-194 was found to be overexpressed in GC cell lines and 43 paired GC tissues. Overexpression of miRNA-194 promoted cell proliferation and migration, while inhibition of miRNA-194 blocked these processes. Inhibition of miRNA-194 decreased tumor volumes in nude mice. Furthermore, miRNA-194 inhibitors promoted cytoplasmic localization of beta-catenin, leading to repression of Wnt signaling. We also discovered that SUFU, a known negative regulator of Hedgehog and Wnt signaling, was a target of miRNA-194. Anti-SUFU siRNAs rescued the inhibitory effects of miRNA-194 antagonists on cell proliferation and migration and on colony formation. We also found that SUFU expression was downregulated in GC tissues and cell lines and negatively correlated with miRNA-194 expression in primary GC tissues. Moreover, SUFU expression was negatively correlated with tumor stage, supporting its potential as a diagnostic or prognostic marker in GC. Taken together, these findings suggest that miRNA-194 is oncogenic and promotes GC cell proliferation and migration by activating Wnt signaling, at least in part, via suppression of SUFU.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/12451]
专题	深圳先进技术研究院_数字所
作者单位	CANCER LETTERS
推荐引用方式 GB/T 7714	Fan, Xinmin,Peng, Yin,Zhang, Xiaojing,et al. MiRNA-194 activates the Wnt/beta-catenin signaling pathway in gastric cancer by targeting the negative Wnt regulator, SUFU.[J]. CANCER LETTERS,2017.
APA	Fan, Xinmin.,Peng, Yin.,Zhang, Xiaojing.,Ma, Qiang.,Yan, Ruibin.,...&Meltzer, Stephen J..(2017).MiRNA-194 activates the Wnt/beta-catenin signaling pathway in gastric cancer by targeting the negative Wnt regulator, SUFU..CANCER LETTERS.
MLA	Fan, Xinmin,et al."MiRNA-194 activates the Wnt/beta-catenin signaling pathway in gastric cancer by targeting the negative Wnt regulator, SUFU.".CANCER LETTERS (2017).