MicroRNA-122 ameliorates corneal allograft rejection through the downregulation of its target CPEB1

	MicroRNA-122 ameliorates corneal allograft rejection through the downregulation of its target CPEB1
	Li F; Wang T; Geng W; Ruan Q; Shi W
刊名	Cell Death Discovery
	2017
文献子类	期刊论文
英文摘要	Transplant rejection is a major cause of corneal transplantation failure. MicroRNAs (miRNAs) are a family of small RNAs that regulates gene expression in a sequence-specific manner. miRNAs have recently been shown to have important roles in human organ transplantation, but reports of miRNAs directly associated with corneal transplantation rejection remain limited. To investigate the role of miRNAs during corneal allograft rejection, we established a mouse penetrating keratoplasty model and used microarrays to screen for differentially expressed miRNAs. Our results revealed that the expression of miR-122 was significantly decreased in the allogeneic group. Consistent with this result, the expression of cytoplasmic polyadenylation element-binding protein-1 (CPEB1), a direct target of miR-122, was significantly increased. Further analysis demonstrated that miR-122 inhibited inflammatory cytokine-induced apoptosis in corneal keratocytes through the downregulation of its target CPEB1. We also found that increased miR-122 expression significantly reduced the risk of corneal transplantation rejection. Thus, our results indicate that miR-122 is an important miRNA associated with corneal graft rejection and can be used as a therapeutic target for the prevention of immune rejection after keratoplasty.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/12286]
专题	深圳先进技术研究院_医药所
作者单位	Cell Death Discovery
推荐引用方式 GB/T 7714	Li F,Wang T,Geng W,et al. MicroRNA-122 ameliorates corneal allograft rejection through the downregulation of its target CPEB1[J]. Cell Death Discovery,2017.
APA	Li F,Wang T,Geng W,Ruan Q,&Shi W.(2017).MicroRNA-122 ameliorates corneal allograft rejection through the downregulation of its target CPEB1.Cell Death Discovery.
MLA	Li F,et al."MicroRNA-122 ameliorates corneal allograft rejection through the downregulation of its target CPEB1".Cell Death Discovery (2017).